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Jul 5, 2024 · G9a/EHMT2 is an important epigenetic modifier that catalyzes the methylation of histone 3 lysine 9 (H3K9) and interacts with various nuclear proteins. In this study, we investigated the role of G9a in osteoclast differentiation.
Teruhito Yamashita's 37 research works with 1,342 citations and 3,559 reads, including: Sclerostin deficiency effectively promotes bone morphogenetic protein-2-induced ectopic bone formation
- Introduction
- Materials and Methods
- Results
- Conclusions
In bone tissue, bone resorption by osteoclasts and bone formation by osteoblasts are repeated continuously. Osteoclasts are multinucleated cells that derive from monocyte-/macrophage-lineage cells and resorb bone. In contrast, osteoblasts mediate osteoclastogenesis by expressing receptor activator of nuclear factor-kappa B ligand (RANKL), which is ...
In this review, we would like to summarize our experimental results on signal transduction that regulates the expression of RANKL and OPG.
Using OPG gene-deficient mice, we have demonstrated that OPG and sclerostin produced by osteocytes play an important role in the maintenance of cortical and alveolar bone. In addition, it was shown that osteoclast-derived leukemia inhibitory factor (LIF) reduces the expression of sclerostin in osteocytes and promotes bone formation. WP9QY (W9) is a...
Bone mass loss depends on the RANK–RANKL–OPG system, which is a major regulatory system of osteoclast differentiation induction, activation, and survival.
Oct 20, 2020 · TLDR. Madecassic acid inhibited osteoclast formation and function in vitro by suppressing NF‐κB, JNK, and NFAT signaling pathways, indicating its potential as a novel drug for the treatment of osteocline‐related bone diseases, especially osteoporosis. Expand. PDF.
Jul 20, 2020 · Ghost of Tsushima: Inari Shrines, Toyotama Region secrets map, video guide. This page of our guide to Ghost of Tsushima has locations of all Inari Shrines in the Toyotama region. Discovering Inari shrines increases the number of charms you can equip.
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Aug 18, 2017 · Shrine locations guide for Zelda: Breath of the Wild has a map for you to find all 120 shrines, get spirit orbs and green Tunic of the Wild
