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Sep 10, 2022 · Statin therapy caused a small excess of mostly mild muscle pain. Most (>90%) of all reports of muscle symptoms by participants allocated statin therapy were not due to the statin. The small risks of muscle symptoms are much lower than the known cardiovascular benefits.
Dec 20, 2022 · Despite clear indications, some studies show that roughly half of patients stop taking statins after six months, and only a quarter of patients with high cardiovascular risk continue with treatment long term. 3 4 Statin associated muscle symptoms, described as myalgia, cramping, or fatigue, are the most common cause of statin intolerance.
This was based on the benefit of statins for reducing the risk of CVD events, particularly non-fatal MI, outweighing the small increase in risk of adverse events (rhabdomyolysis, muscle pain, raised liver transaminases and new-onset diabetes).
- 2023/05
Muscle symptoms are a clinically relevant side effect of statin treatment. Methods. This review is based on pertinent publications retrieved by a selective literature search, and on the current recommendations of the European Atherosclerosis Society. Results. At least 5% of patients taking statins have statin-associated muscle symptoms (SAMS).
Jul 15, 2021 · In this systematic review of randomised controlled trials, we examined the associations between statins and adverse events in adults without a history of cardiovascular disease. We found a slightly increased risk of self-reported muscle symptoms after treatment with statins but no increased risk of clinically confirmed muscle disorders.
- Ting Cai, Lucy Abel, Oliver Langford, Genevieve Monaghan, Jeffrey K Aronson, Richard J Stevens, Sara...
- 2021
Feb 24, 2021 · We describe the results of StatinWISE (Statin Web-based Investigation of Side Effects), a series of n-of-1 trials comparing treatment periods of statins and placebo in people who had previously reported muscle symptoms when taking statins.
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Feb 27, 2020 · Rarely is it possible to establish a causal link between statins and muscle pain. In randomized controlled trials, statins are well tolerated, and muscle-pain related side-effects is similar to placebo. There are also nocebo effects of statins.
