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Mar 5, 2024 · Athletes are more prone to the development of statin-associated muscle symptoms (SAMS); however, there is inconclusive evidence to support a pathophysiologic effect of statins on muscle weakness or reduced aerobic capacity.
Dec 20, 2022 · Fresh evidence adds confidence to shared decision making about statins. Inhibitors of hydroxymethylglutaryl coenzyme A reductase (statins) are among the most widely investigated and prescribed drugs in cardiovascular medicine, and they have substantial effects on the outcomes of atherosclerotic cardiovascular disease. 1 2 Leading guidelines ...
Despite the salutary effects, there are some unintended consequences of statins, including being linked to muscle pain, cramps, and fatigue, which may lead to reduced levels of physical activity (PA) and/or structured aerobic exercise.
- Barry A. Franklin, Carl J. Lavie
- 2015
Feb 24, 2021 · We describe the results of StatinWISE (Statin Web-based Investigation of Side Effects), a series of n-of-1 trials comparing treatment periods of statins and placebo in people who had previously reported muscle symptoms when taking statins.
- E Herrett, E Williamson, K Brack, D Beaumont, A Perkins, A Thayne, H Shakur-Still, I Roberts, D Prow...
- 2021
Simultaneously, physical activity is increasingly recognized and recommended to reduce CVD risk. 9 Statin-associated musculoskeletal side effects, exacerbated by recommended physical activity, could lead to reduced statin use in individuals who would benefit from statin therapy. This review explores mechanisms that may increase the risk of ...
None of the studies showed a relationship between statins use and exercise and an increase in myalgia or a decrease in exercise performance. There was also no correlation between intensity of statin therapy and an effect on these variables.
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Mar 2, 2022 · Moderate-intensity exercise can improve muscle performance without changing frequency or intensity of muscle complaints. Clinicians may feel more assured to advocate for moderate-intensity exercise in select patients taking statins with or without muscle symptoms.
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