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Jan 3, 2018 · The collaboration among scientists that ultimately produced concrete evidence of the DNA replication mechanism furthered both theoretical and physical explanations of genetics and molecular biology, providing insight into how life develops, reproduces, and evolves.
Conceptually, semiconservative replication made sense in light of the double helix structural model of DNA, in particular its complementary nature and the fact that adenine always pairs with...
The methods Meselson and Stahl developed allowed them to distinguish existing DNA from newly synthesized DNA and to track new and old DNA over several rounds of replication. They accomplished this by labeling cells with different stable isotopes of nitrogen.
DNA replication takes place at a Y-shaped structure called a replication fork. A self-correcting DNA polymerase enzyme catalyzes nucleotide polymerization in a 5′-to-3′ direction, copying a DNA template strand with remarkable fidelity.
- Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter
- 2002
- 2002
(C) The “classical” End Replication Problem leading to progressive telomere shortening is the consequence of the unusual DNA structure of telomeres, i.e., the constitutive 3′ overhang, that has to be reformed after conventional replication, and the unidirectionality of DNA synthesis by conventional replicative DNA polymerase (from 5′ to 3′). Indeed, the G-rich strand (blue line) is ...
The two men behind the laborious steps in discovering the semiconservative replication of DNA credit much of their success to timing, hard work, and serendipity. A Partnership Begins.
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May 24, 2017 · The termination of DNA replication involves convergence of replication forks, the completion of DNA synthesis, replisome disassembly and the decatenation of daughter DNA molecules.
