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Mar 31, 2021 · The reviews were published in March 2021. The review of GnRH agonists (puberty blockers) makes for sobering reading. Its major finding is that GnRH agonists lead to little or no change in gender dysphoria, mental health, body image and psychosocial functioning. In the few studies that did report change, the results could be attributable to bias ...
Oct 17, 2021 · The NICE Review of gonadotropin-releasing hormone analogues (GnRHa), medications that block the production of the sex hormones testosterone and estrogen and are used to treat gender dysphoria in adolescents, was published in March 2021. The review included nine observational studies published no later than October 14, 2020: five retrospective studies, three prospective longitudinal studies ...
Aug 3, 2017 · Hormone replacement therapy, or HRT, first became available in 1940 and proved for many years to be a complete life saver for millions of women. It controlled, or stopped entirely, their symptoms of menopause, effectively alleviating hot flushes, vaginal dryness, osteoporosis, joint pain, and memory loss, among other things. However, the therapy got a bad rep in 2002 and 2003 when the results ...
The traditional endocrine treatment arsenal consists of luteinizing hormone-releasing hormone (LHRH) agonists, selective estrogen receptor modulators (SERMs), aromatase inhibitors (AIs) and fulvestrant, a selective estrogen receptor degrader (SERD) . In endocrine sensitive hormone receptor positive metastatic breast cancer AI combined with a cyclin dependent kinase 4/6 inhibitor (CDK4/6i) is ...
Apr 1, 2021 · Puberty blockers, known scientifically as gonadotrophin-releasing hormone (GnRH) analogues, are prescribed to some young people with gender dysphoria - distress caused by a discrepancy between a ...
Leuprolide, a gonadotropin releasing hormone (GnRH) agonist that induces ovarian suppression, has been shown to reduce premenstrual symptoms when dosed monthly as a 3.75mg depot compared to placebo. 23 Although a meta-analysis concludes that add-back hormone therapy to reduce the side effects of ovarian suppression does not sacrifice efficacy, 24 leuprolide has a significant side effect burden ...
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What is hormone replacement therapy (HRT)?
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Apr 5, 2023 · Anti-estrogen therapy is a key component of the treatment of both early and advanced-stage hormone receptor (HR)-positive breast cancer. This review discusses the recent emergence of several anti ...
