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1. www.bbc.com › news › health-56601386Evidence for puberty blockers use very low, says NICE - BBC

   www.bbc.com › news › health-56601386

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   Apr 1, 2021 · Puberty blockers, known scientifically as gonadotrophin-releasing hormone (GnRH) analogues, are prescribed to some young people with gender dysphoria - distress caused by a discrepancy...

2. sciencebasedmedicine.org › a-critical-look-at-theConclusions Not So NICE: A Critical Analysis of the NICE ...

   sciencebasedmedicine.org › a-critical-look-at-the

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   Oct 17, 2021 · In 2020, the UK National Institute for Health and Care Excellence (NICE) undertook two systematic evidence reviews of the use of GnRH agonists (also known as “puberty blockers”) and cross-sex hormones as treatments for gender dysphoric patients <18 years old.

3. segm.org › NICE_gender_medicine_systematic_reviewNew Systematic Reviews of Puberty Blockers and Cross-Sex ...

   segm.org › NICE_gender_medicine_systematic_review

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   Mar 31, 2021 · In 2020, the UK National Institute for Health and Care Excellence (NICE) undertook two systematic evidence reviews of the use of GnRH agonists (also known as "puberty blockers") and cross-sex hormones as treatments for gender dysphoric patients <18 years old.

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5. segm.org › sites › defaultEvidence review: Gonadotrophin releasing hormone analogues ...

   segm.org › sites › default

   This review aims to assess the evidence for the clinical effectiveness, safety and cost- effectiveness of gonadotrophin releasing hormone (GnRH) analogues for children and adolescents aged 18 years or under with gender dysphoria.

6. www.thelancet.com › pdfs › journalsPuberty blockers for gender dysphoria: the science is far ...

   www.thelancet.com › pdfs › journals

   tropin hormone-releasing hormone (GnRH) analogues (also known as puberty blockers) to young people with gender dysphoria is a proven, life-saving treatment akin to giving insulin to type 1 diabetics. Baams’ assertion that puberty blockers prevent suicidality can be traced to a paper by Turban and colleagues, 3. which has been thoroughly critiqued

7. transfemscience.org › articles › puberty-blockersPuberty Blockers: A Review of GnRH Analogues in Transgender ...

   transfemscience.org › articles › puberty-blockers

   Jan 30, 2022 · Unlike hormone therapy, no risk of permanent infertility is believed to exist with the use of puberty blockers. Several long-term follow-up studies of patients treated with puberty blockers have found normal fertility.

8. People also ask

   Are gonado-tropin hormone-releasing hormone (GnRH) analogues a life-saving treatment for gender DYS?

   • From the Editorial1 and Baams’ related Comment,2 readers might perceive that administering gonado-tropin hormone-releasing hormone (GnRH) analogues (also known as puberty blockers) to young people with gender dysphoria is a proven, life-saving treatment akin to giving insulin to type 1 diabetics.

   Puberty blockers for gender dysphoria: the science is far from settled

   www.thelancet.com/pdfs/journals/lanchi/PIIS2352-4642(21)00235-2.pdf

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   Are gender-affirming hormones a cost-effective treatment for gender dysphoria?

   • The review found no evidence of cost-effectiveness of treatment. NICE also reviewed the evidence base for gender-affirming hormones - sometimes known as cross-sex hormones. These can be given to young people with gender dysphoria from age 16 in the NHS.

   Evidence for puberty blockers use very low, says NICE - BBC

   www.bbc.com/news/health-56601386

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   Is there a roadblock to gender-affirming care?

   • The NICE review of puberty blockers has been favorably commented on by the Society for Evidence-Based Gender Medicine (SEGM), who have used it to argue against gender-affirming care. Opponents to gender-affirming care, such as Stephen B. Levine, have also cited this source.

   conclusions not so nice: a critical analysis of the nice evidence

   sciencebasedmedicine.org/a-critical-look-at-the-nice-review/

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   Can hormone treatment change a'regression-to-the-mean' score?

   • The reviewers noted that “a fundamental limitation of all the uncontrolled studies in this review is that any changes in scores from baseline to follow-up could be attributed to a regression-to-the-mean,” rather than the beneficial effects of hormone treatment.

   New Systematic Reviews of Puberty Blockers and Cross-Sex Hormones

   segm.org/NICE_gender_medicine_systematic_review_finds_poor_quality_evidence

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   Does gonadotropin-releasing hormone analog treatment affect reproductive axis?

   • Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty. The Journal of Clinical Endocrinology and Metabolism, 84 (1), 44–49.

   Puberty Blockers: A Review of GnRH Analogues in Transgender Youth

   transfemscience.org/articles/puberty-blockers/

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   Can hormone therapy cause negative outcomes in trans girls?

   • Combined with the results of trans boys, this suggests that not puberty blockers themselves, but rather, subsequent suboptimal hormone therapy in trans girls could potentially be to blame for their more pronounced negative outcomes. The hormone therapy prescribed to trans girls in the listed studies may be suboptimal in several ways.

   Puberty Blockers: A Review of GnRH Analogues in Transgender Youth

   transfemscience.org/articles/puberty-blockers/

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9. pubmed.ncbi.nlm.nih.gov › 33320999Review: Puberty blockers for transgender and gender diverse ...

   pubmed.ncbi.nlm.nih.gov › 33320999

   Pediatric healthcare providers supported by professional guidelines are treating many of these children with gonadotropin-releasing hormone agonists (GnRHa), which reversibly block pubertal development, giving the child and their family more time in which to explore the possibility of medical transition.