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Oct 17, 2021 · The NICE Review of gonadotropin-releasing hormone analogues (GnRHa), medications that block the production of the sex hormones testosterone and estrogen and are used to treat gender dysphoria in adolescents, was published in March 2021. The review included nine observational studies published no later than October 14, 2020: five retrospective studies, three prospective longitudinal studies ...
This review aims to assess the evidence for the clinical effectiveness, safety and cost-effectiveness of gonadotrophin releasing hormone (GnRH) analogues for children and adolescents aged 18 years or under with gender dysphoria. The review follows the NHS England Specialised Commissioning process and template and is based on the criteria
Apr 1, 2021 · The evidence for using puberty blocking drugs to treat young people struggling with their gender identity is "very low", an official review has found. The National Institute of Health and Care ...
tropin hormone-releasing hormone (GnRH) analogues (also known as puberty blockers) to young people with gender dysphoria is a proven, life-saving treatment akin to giving insulin to type 1 diabetics. Baams’ assertion that puberty blockers prevent suicidality can be traced to a paper by Turban and colleagues, 3. which has been thoroughly critiqued
The evidence reviews were published in March 2021. Unfortunately, the available evidence was not deemed strong enough to form the basis of a policy position. National Institute for Health and Care Excellence (2020). Evidence Review: Gonadotrophin Releasing Hormone Analogues for Children and Adolescents with Gender Dysphoria.
Mar 31, 2021 · In 2020, the UK National Institute for Health and Care Excellence (NICE) undertook two systematic evidence reviews of the use of GnRH agonists (also known as "puberty blockers") and cross-sex hormones as treatments for gender dysphoric patients <18 years old. These reviews were commissioned by NHS England, as part of a review of gender dysphoria healthcare led by Dr Hilary Cass OBE.
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Jan 30, 2022 · Discontinuation rates for patients on puberty blockers are very low, with fewer than 5% of teens typically stopping them without going on to hormone therapy (Wiepjes et al., 2018; Brik et al., 2020; Kuper et al., 2020). A potential concern is that this could mean puberty blockers put children on an almost guaranteed path towards gender transition, when they might otherwise change their minds.