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1. segm.org › sites › defaultEvidence review: Gonadotrophin releasing hormone analogues ...

   segm.org › sites › default

   This review aims to assess the evidence for the clinical effectiveness, safety and cost-effectiveness of gonadotrophin releasing hormone (GnRH) analogues for children and adolescents aged 18 years or under with gender dysphoria. The review follows the NHS England Specialised Commissioning process and template and is based on the criteria

2. sciencebasedmedicine.org › a-critical-look-at-theConclusions Not So NICE: A Critical Analysis of the NICE ...

   sciencebasedmedicine.org › a-critical-look-at-the

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   Oct 17, 2021 · The NICE Review of gonadotropin-releasing hormone analogues (GnRHa), medications that block the production of the sex hormones testosterone and estrogen and are used to treat gender dysphoria in adolescents, was published in March 2021. The review included nine observational studies published no later than October 14, 2020: five retrospective studies, three prospective longitudinal studies ...

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     5 Common Side Effects Of Hormone Replacement Therapy (HRT) | Maryon Stewart

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     Considering hormone replacement therapy (HRT)? Here’s what you should know - Online interview

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4. www.thelancet.com › pdfs › journalsPuberty blockers for gender dysphoria: the science is far ...

   www.thelancet.com › pdfs › journals

   tropin hormone-releasing hormone (GnRH) analogues (also known as puberty blockers) to young people with gender dysphoria is a proven, life-saving treatment akin to giving insulin to type 1 diabetics. Baams’ assertion that puberty blockers prevent suicidality can be traced to a paper by Turban and colleagues, 3. which has been thoroughly critiqued

5. thebms.org.uk › wp-content › uploadsBMS & WHC’s 2020 recommendations on hormone replacement ...

   thebms.org.uk › wp-content › uploads

   MS & WHC’s 2020 recommendations on hormone replacement therapy in menopausal womenThe British Menopause Society (. MS) is the specialist authority for menopause and post reproductive health in the UK. The BMS educates, informs and guides healthcare professionals, working in both. primary and secondary care, on menopause and all aspects of ...

6. www.bbc.com › news › health-56601386Evidence for puberty blockers use very low, says NICE - BBC

   www.bbc.com › news › health-56601386

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   Apr 1, 2021 · Puberty blockers, known scientifically as gonadotrophin-releasing hormone (GnRH) analogues, are prescribed to some young people with gender dysphoria - distress caused by a discrepancy between a ...

7. cass.independent-review.uk › nice-evidence-reviewsNice Evidence Reviews – Cass Review

   cass.independent-review.uk › nice-evidence-reviews

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   The evidence reviews were published in March 2021. Unfortunately, the available evidence was not deemed strong enough to form the basis of a policy position. National Institute for Health and Care Excellence (2020). Evidence Review: Gonadotrophin Releasing Hormone Analogues for Children and Adolescents with Gender Dysphoria.

8. People also ask

   Are gonado-tropin hormone-releasing hormone (GnRH) analogues a life-saving treatment for gender DYS?

   • From the Editorial1 and Baams’ related Comment,2 readers might perceive that administering gonado-tropin hormone-releasing hormone (GnRH) analogues (also known as puberty blockers) to young people with gender dysphoria is a proven, life-saving treatment akin to giving insulin to type 1 diabetics.

   Puberty blockers for gender dysphoria: the science is far from settled

   www.thelancet.com/pdfs/journals/lanchi/PIIS2352-4642(21)00235-2.pdf

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   Are gender-affirming hormones a cost-effective treatment for gender dysphoria?

   • The review found no evidence of cost-effectiveness of treatment. NICE also reviewed the evidence base for gender-affirming hormones - sometimes known as cross-sex hormones. These can be given to young people with gender dysphoria from age 16 in the NHS.

   Evidence for puberty blockers use very low, says NICE - BBC

   www.bbc.com/news/health-56601386

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   Can GnRH agonists treat gender dysphoric patients 18 years old?

   • In 2020, the UK National Institute for Health and Care Excellence (NICE) conducted two systematic evidence reviews on the use of GnRH agonists (also known as 'puberty blockers') as treatments for gender dysphoric patients who are under 18 years old.

   conclusions not so nice: a critical analysis of the nice evidence

   sciencebasedmedicine.org/a-critical-look-at-the-nice-review/

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   How long should hormone replacement therapy (HRT) be delivered?

   • Within Hormone Replacement Therapy (HRT) regimens, this should be delivered for at least the same duration as that produced during the luteal phase of the monthly cycle and in the recommended doses to protect against the risk of endometrial hyperplasia and endometrial cancer. 1 – 3

   British Menopause Society tools for clinicians: Progestogens and

   journals.sagepub.com/doi/full/10.1177/20533691211058030

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   When should a non-hysterectomised woman take HRT?

   • aged to use HRT at least until the average age of the menopause.Routes and regimens Non-hysterectomised women require progestogen (administered for 12-14 days in a sequential regimen and daily in a continuous combined regimen) to minimise the risk of endom

   BMS & WHC’s 2020 recommendations on hormone replacement therap…

   thebms.org.uk/wp-content/uploads/2023/10/02-BMS-ConsensusStatement-BMS-WHC-2020-Recommendations-on-HRT-in-menopausal-women-SEPT2023-A.pdf

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   Can a cyclical HRT regimen be changed?

   • duled bleeding, the HRT regimen could be changed to a cyclical intake of progestogen.For cyclical HRT regimens, the dose of progestogen could be increased (e.g. micronised progesterone 300 mg for 12 days a month instead of 200 mg) or increase duration of progestogen intake (can

   BMS & WHC’s 2020 recommendations on hormone replacement therap…

   thebms.org.uk/wp-content/uploads/2023/10/02-BMS-ConsensusStatement-BMS-WHC-2020-Recommendations-on-HRT-in-menopausal-women-SEPT2023-A.pdf

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9. journals.sagepub.com › doi › fullBritish Menopause Society tools for clinicians: Progestogens ...

   journals.sagepub.com › doi › full

   Nov 27, 2021 · A systematic review by Stute et al. (2016) assessed the impact of micronized progesterone on the endometrium. Forty studies were included in the systematic review and it concluded that oral micronized progesterone provides endometrial protection if applied sequentially for 12–14 days/month in a dose of 200 mg/day for up to five years. 18