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  1. Jul 23, 2019 · Here, we proposed a new, bottom-up conceptual paradigm: The Energy Homeostasis Principle, where the balance between energy income, expenditure, and availability are the key parameters in determining the dynamics of neuronal phenomena found from molecular to behavioral levels.

  2. Jun 22, 2018 · To compensate for varying energy demands throughout the brain and to increase efficiency of metabolite supply, neurovascular and neurometabolic coupling mechanisms have evolved to enhance blood flow and utilization of metabolites in areas of neural activity.

    • Michelle E. Watts, Roger Pocock, Charles Claudianos, Charles Claudianos
    • 10.3389/fnmol.2018.00216
    • 2018
    • Front Mol Neurosci. 2018; 11: 216.
  3. Mar 17, 2022 · The hypothalamus is a brain region thought to play a critical role in the regulation of energy homeostasis 1. In this review, we summarized the components of energy expenditure at the organism...

  4. Jul 6, 2021 · Our brain is energy hungry and consumes about 2025% of the energy of the whole body despite representing only 2% of the body mass. Most of this energy, around 80–90%, is spent for its spontaneous activity, as measured in the resting state, that is, without any specific task demands.

    • Yali Chen, Jun Zhang
    • 10.3389/fnsys.2021.648860
    • 2021
    • Front Syst Neurosci. 2021; 15: 648860.
  5. Mar 11, 2016 · Substantial evidence indicates that the brain, particularly the hypothalamus, is primarily responsible for the regulation of energy homeostasis. 1 The brain monitors changes in the body energy...

    • Eun Roh, Do Kyeong Song, Do Kyeong Song, Min-Seon Kim, Min-Seon Kim
    • 2016
  6. Brain energy metabolism is regulated by a coordinated and cell-specific exchange of signals and metabolic substrates between neurons and astrocytes. Magistretti and Allaman review these mechanisms, their role in functional brain imaging, and their implications for human brain evolution.

  7. Jan 11, 2022 · Astrocytes play key roles in the regulation of brain energy metabolism, which has a major impact on brain functions, including memory, neuroprotection, resistance to oxidative stress and homeostatic tone.

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