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B cells have a variety of immune functions including antigen presentation, antibody production, and direct antigen pick up through their B cell receptor (BCR). 1,2 Recently, the newly designated B cells, called regulatory B cells (Breg) have been found to exert negative immunoregulatory activity. 3 Breg cells, the collective name of several ...
Apr 21, 2015 · Abstract. Regulatory B (Breg) cells are immunosuppressive cells that support immunological tolerance. Through the production of interleukin-10 (IL-10), IL-35, and transforming growth factor β (TGF-β), Breg cells suppress immunopathology by prohibiting the expansion of pathogenic T cells and other pro-inflammatory lymphocytes.
- Elizabeth C. Rosser, Claudia Mauri
- 2015
Oct 21, 2020 · 2 Department of Oncology, PLA Rocket Force Characteristic Medical Center, Beijing, China. In immune system, B cells are classically positive modulators that regulate inflammation and immune responses. Regulatory B cells (Bregs) are a subset of B cells which play crucial roles in various conditions, including infection, allergies, autoimmune ...
Highlights. Regulatory B cells (Bregs) are a subpopulation of B cells that have immunosuppressive effects. The defective function of Bregs can lead to a dysregulated innate and adaptive immune responses. B regs contribute to increased regulatory cytokines and leads to the induction of T regs. B regs is associated with viral and bacterial load ...
- Gene Expression. Introduction. All cells control when and how much each one of its genes are expressed. This simple statement - one that could be derived simply from observing cellular behavior - brings up many questions that we can begin to lay out using our Design Challenge rubric.
- The design challenge of regulating gene expression. To drive this discussion from a design challenge perspective, we can formally stipulate that the "big problem" we are interested in understating is that of regulating protein abundance in a cell.
- Activation and Repression of Transcription. Some basics. Let us consider a protein coding gene and work through some logic. We start by imagining a simple case, where a protein-coding gene is encoded by a single contiguous stretch of DNA.
- States of a regulated promoter. Since promoters recruit an RNA polymerase these sites and the assembly of the pre-initiation complex are obvious sites for regulating the first steps of gene expression.
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What is epigenetic regulation?
The process of gene expression requires multiple steps depending on what the fate of the final product will be. In the case of structural and regulatory RNAs (i.e. tRNA, rRNA, snRNA, etc.) the process requires that a gene be transcribed and that any needed post-transcriptional processing take place.
