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- A mutation in the PIK3CA gene can cause cells to divide and replicate uncontrollably. It contributes to the growth of many cancers, including metastatic breast cancer (MBC).
www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer
People also ask
What is a PIK3CA mutation?
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Mar 1, 2024 · PIK3CA mutations are found in up to 40% of estrogen receptor (ER)-positive, HER2-negative breast cancers. If your tumor is found to have a PIK3CA mutation, new treatments that specifically target...
- Jacquelyn Cafasso
Feb 2, 2024 · In a 2019 phase 3 clinical trial (SOLAR-1) published in the New England Journal of Medicine, the combination of Piqray and Faslodex (fulvestrant) almost doubled the progression-free survival rate of people with metastatic breast cancer positive for PIK3CA mutations from 5.7 months to 11.0 months.
Oct 17, 2024 · Mutations in the phosphatidylinositol-3-kinase alpha isoform gene (PIK3CA) have been shown to be drivers of uncontrolled tumor growth, disease progression and resistance to endocrine-based...
Aug 8, 2022 · PIK3CA encodes the class I PI3Kα isoform and is frequently mutated in cancer. Activating mutations in PIK3CA also cause a range of congenital disorders featuring asymmetric tissue...
Mar 29, 2023 · Studies of PIK3CA (phosphatidylinosoitol-4,5-bisphosphate 3-kinase catalytic subunit alpha) have shown that abnormal signaling in the PI3K pathway is related to tumorigenesis,...
Jan 31, 2020 · An analysis of outcomes and molecular landscape of patients with PIK3CA -mutated metastatic breast cancer (MBC) from the SAFIR02 trial showed that patients with PIK3CA- mutated hormone receptor (HR)-positive/HER2-negative tumours have a poor outcome and resistance to chemotherapy.
Jul 15, 2024 · In their discussion, the key opinion leaders explore the significance of PIK3CA mutations in HR+/HER2- metastatic breast cancer and review the findings from two pivotal clinical trials, SOLAR-1 and...
