Yahoo Web Search

Search results

1. www.healthline.com › health › metastatic-breastPIK3CA Mutation in Metastatic Cancer: Treatment and More

   www.healthline.com › health › metastatic-breast

   • Cached

   Mar 1, 2024 · PIK3CA mutations are found in up to 40% of estrogen receptor (ER)-positive, HER2-negative breast cancers. If your tumor is found to have a PIK3CA mutation, new treatments that specifically...

   • Author: Jacquelyn Cafasso

2. ascopubs.org › doi › 10PIK3CA Mutations Drive Therapeutic Resistance in Human ...

   ascopubs.org › doi › 10

   Mar 31, 2022 · Somatic activating mutations in the gene encoding PI3K alpha catalytic subunit (PIK3CA) are present in approximately 30% of early-stage HER2+ tumors and drive therapeutic resistance to multiple HER2-targeted agents.

3. www.verywellhealth.com › pik3ca-mutations-in-metaPIK3CA Mutations in Metastatic Breast Cancer - Verywell Health

   www.verywellhealth.com › pik3ca-mutations-in-meta

   • Cached

   Feb 2, 2024 · In a 2019 phase 3 clinical trial (SOLAR-1) published in the New England Journal of Medicine, the combination of Piqray and Faslodex (fulvestrant) almost doubled the progression-free survival rate of people with metastatic breast cancer positive for PIK3CA mutations from 5.7 months to 11.0 months.

4. www.esmo.org › oncology-news › pik3ca-mutated-metaPIK3CA-mutated Metastatic Breast Cancer - ESMO

   www.esmo.org › oncology-news › pik3ca-mutated-meta

   • Cached

   Jan 31, 2020 · An analysis of outcomes and molecular landscape of patients with PIK3CA -mutated metastatic breast cancer (MBC) from the SAFIR02 trial showed that patients with PIK3CA- mutated hormone receptor (HR)-positive/HER2-negative tumours have a poor outcome and resistance to chemotherapy.

5. www.ncbi.nlm.nih.gov › pmc › articlesPrognostic role of PIK3CA mutations of cell‐free DNA in early ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 30, 2015 · We investigated the PIK 3 CA major mutation status of cf DNA as a noninvasive biomarker of cancer using droplet digital polymerase chain reaction (dd PCR), which has high level sensitivity and specificity for cancer mutation, in early‐stage 49 triple negative breast cancer (TNBC) patients.

   • Author: Takashi Takeshita, Yutaka Yamamoto, Mutsuko Yamamoto-Ibusuki, Touko Inao, Aiko Sueta, Saori Fujiwara...
   • DOI: 10.1111/cas.12813

   • Publish Year: 2015
   • Publication: Cancer Sci. 2015 Nov; 106(11): 1582-1589.

6. Videos

   • 

     2:34:05

     youtube.com

     Chuyện Tình Ca Sĩ | Ca Sĩ Ngọc Hân | Ngọc Hân Official

     25 May 2017

     748.4K views

   • 

     3:47

     youtube.com

     Tiền - Ngọc Sơn | Liveshow Duyên Phận Bolero 2017

     30 May 2017

     4.4M views

   • 

     4:57

     youtube.com

     Hà Tiên - Ngọc Huyền | ASIA 52

     5 Oct 2017

     163.8K views

   View all

7. www.frontiersin.org › journals › oncologyFrontiers | PIK3CA Mutations as a Molecular Target for ...

   www.frontiersin.org › journals › oncology

   • Cached

   Mar 24, 2021 · Overall, ~40% of hormone receptor (HR) + /HER2 − MBC cases harbor alterations affecting the (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. This pathway is a major target in oncogenesis, as it regulates growth, proliferation, cell survival, and angiogenesis.

8. atlasgeneticsoncology.org › gene › 415PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide)

   atlasgeneticsoncology.org › gene › 415

   • Cached

   Jun 1, 2018 · Description. The PIK3CA gene spans a total genomic size of 86,190 bases and is composed of 21 exons, 20 of them coding exons of varying lengths. Putative pseudogenes of PIK3CA have been described on chromosomes 16 (gi 28913054) and 22q11.2 (gi 5931525), the later one in the Cat Eye Syndrome region.

9. People also ask

   What is a PIK3CA mutation in breast cancer?

   • PIK3CA mutations are found in up to 40% of estrogen receptor (ER)-positive, HER2-negative breast cancers. If your tumor is found to have a PIK3CA mutation, new treatments that specifically target the mutation in the PIK3CA gene could be helpful. How are PIK3CA mutations related to metastatic breast cancers?

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

   See all results for this question

   Does PIK3CA mutated triple-negative breast cancer improve survival?

   • Patients with PIK3CA- mutated triple-negative breast cancer (TNBC) present a better overall survival (OS). This could be explained by an enrichment of PIK3CA mutations in luminal breast cancer which lost HR expression in the metastatic setting. The results were published online on 24 January 2020 in the Annals of Oncology.

   PIK3CA-mutated Metastatic Breast Cancer - ESMO

   www.esmo.org/oncology-news/pik3ca-mutated-metastatic-breast-cancer

   See all results for this question

   Does PIK3CA mean if you have triple-positive breast cancer?

   • A 2022 study found the 5-year overall survival for triple-positive breast cancer was 96.7% within the study group. If you have MBC, knowing your PIK3CA gene status can be helpful if your cancer hasn’t improved or has come back after treatment, especially if you have HR-positive and HER2-negative breast cancer.

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

   See all results for this question

   What is PI3K alpha catalytic subunit (PIK3CA)?

   • Somatic activating mutations in the gene encoding PI3K alpha catalytic subunit (PIK3CA) are present in approximately 30% of early-stage HER2+ tumors and drive therapeutic resistance to multiple HER2-targeted agents.

   PIK3CA Mutations Drive Therapeutic Resistance in Human

   ascopubs.org/doi/10.1200/PO.21.00370

   See all results for this question

   What is PIK3CA gene?

   • PIK3CA is a gene that, when mutated, can cause cells to divide and replicate uncontrollably. It contributes to the growth of many cancers, including metastatic breast cancer.

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

   See all results for this question

   Does PIK3CA cause cancer?

   • In addition to playing a role in many breast cancers, PIK3CA mutations have been noted in a dozen other cancers, particularly uterine cancer, bladder cancer, colon cancer, and head and neck cancers.

   PIK3CA Mutations in Metastatic Breast Cancer - Verywell Health

   www.verywellhealth.com/pik3ca-mutations-in-metastatic-breast-cancer-4689488

   See all results for this question