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1. www.healthline.com › health › metastatic-breastPIK3CA Mutation in Metastatic Cancer: Treatment and More

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   Mar 1, 2024 · PIK3CA mutations are found in up to 40% of estrogen receptor (ER)-positive, HER2-negative breast cancers. If your tumor is found to have a PIK3CA mutation, new treatments that specifically...

   • Author: Jacquelyn Cafasso

2. www.verywellhealth.com › pik3ca-mutations-in-metaPIK3CA Mutations in Metastatic Breast Cancer - Verywell Health

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   Feb 2, 2024 · In a 2019 phase 3 clinical trial (SOLAR-1) published in the New England Journal of Medicine, the combination of Piqray and Faslodex (fulvestrant) almost doubled the progression-free survival rate of people with metastatic breast cancer positive for PIK3CA mutations from 5.7 months to 11.0 months.

3. www.esmo.org › oncology-news › pik3ca-mutated-metaPIK3CA-mutated Metastatic Breast Cancer - ESMO

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   Jan 31, 2020 · Patients with PIK3CA- mutated triple-negative breast cancer (TNBC) present a better overall survival (OS). This could be explained by an enrichment of PIK3CA mutations in luminal breast cancer which lost HR expression in the metastatic setting.

4. medlineplus.gov › genetics › genePIK3CA gene - MedlinePlus

   medlineplus.gov › genetics › gene

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   The PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). Learn about this gene and related health conditions.

5. www.mycancergenome.org › content › genePIK3CA - My Cancer Genome

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   PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) is a gene that encodes the protein phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, a subunit of the PI3K protein.

6. executive.nhs.wales › functions › networks-andPIK3CA-mutated breast cancer clinical guidance document

   executive.nhs.wales › functions › networks-and

   phosphatidylinositol 3-kinase (PI3K) testing pathway in hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer in adults. The guidance is relevant to all staff involved with the management of adults who are eligible to have their tumour tested for this genetic biomarker.

7. People also ask

   What is a PIK3CA mutation?

   • A mutation in the PIK3CA gene can cause cells to divide and replicate uncontrollably. It contributes to the growth of many cancers, including metastatic breast cancer (MBC). If your tumor has a PIK3CA mutation, new treatments that specifically target this mutation could be used to treat your cancer.

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

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   Is PIK3CA a cancer?

   • Mutant PIK3CA has been implicated in the pathogenesis of several cancers, including colon cancer, glioma, gastric cancer, breast cancer, endometrial cancer, and lung cancer (COSMIC; PMID: 15016963).

   PIK3CA - My Cancer Genome

   www.mycancergenome.org/content/gene/PIK3CA/

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   Does PIK3CA mean if you have triple-positive breast cancer?

   • A 2022 study found the 5-year overall survival for triple-positive breast cancer was 96.7% within the study group. If you have MBC, knowing your PIK3CA gene status can be helpful if your cancer hasn’t improved or has come back after treatment, especially if you have HR-positive and HER2-negative breast cancer.

   PIK3CA Mutation in Metastatic Cancer: Treatment and More - Healthline

   www.healthline.com/health/metastatic-breast-cancer/pik3ca-mutation-and-breast-cancer

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   Does PIK3CA mutated triple-negative breast cancer improve survival?

   • Patients with PIK3CA- mutated triple-negative breast cancer (TNBC) present a better overall survival (OS). This could be explained by an enrichment of PIK3CA mutations in luminal breast cancer which lost HR expression in the metastatic setting. The results were published online on 24 January 2020 in the Annals of Oncology.

   PIK3CA-mutated Metastatic Breast Cancer - ESMO

   www.esmo.org/oncology-news/pik3ca-mutated-metastatic-breast-cancer

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   Does Piqray (Alpelisib) cause PIK3CA mutations in breast cancer?

   • The medication Piqray (alpelisib) was approved in May of 2019 for postmenopausal women and men with metastatic breast cancer that has progressed on endocrine therapy. In discussing PIK3CA mutations in breast cancer it's important to note that this mutation can coexist with other genetic alterations (such as HER2).

   PIK3CA Mutations in Metastatic Breast Cancer - Verywell Health

   www.verywellhealth.com/pik3ca-mutations-in-metastatic-breast-cancer-4689488

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   What does PIK3CA stand for?

   • PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) is a gene that encodes the protein phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, a subunit of the PI3K protein.

   PIK3CA - My Cancer Genome

   www.mycancergenome.org/content/gene/PIK3CA/

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8. www.mycancergenome.org › content › alterationPIK3CA Mutation - My Cancer Genome

   www.mycancergenome.org › content › alteration

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   PIK3CA Mutation is present in 12.16% of AACR GENIE cases, with breast invasive ductal carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, lung adenocarcinoma, and breast invasive lobular carcinoma having the greatest prevalence [4].