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Mar 1, 2024 · PIK3CA mutations are found in up to 40% of estrogen receptor (ER)-positive, HER2-negative breast cancers. If your tumor is found to have a PIK3CA mutation, new treatments that specifically...
- Jacquelyn Cafasso
Feb 2, 2024 · In a 2019 phase 3 clinical trial (SOLAR-1) published in the New England Journal of Medicine, the combination of Piqray and Faslodex (fulvestrant) almost doubled the progression-free survival rate of people with metastatic breast cancer positive for PIK3CA mutations from 5.7 months to 11.0 months.
Jan 31, 2020 · Patients with PIK3CA- mutated triple-negative breast cancer (TNBC) present a better overall survival (OS). This could be explained by an enrichment of PIK3CA mutations in luminal breast cancer which lost HR expression in the metastatic setting.
Jul 15, 2022 · The Expert Panel found the strongest support for widespread testing for PIK3CA somatic variants, germline BRCA1/2 mutations, and PD-L1 expression. Using the correct assay for each biomarker is an important part of treatment planning and is becoming increasingly complicated.
Mar 11, 2024 · Characterizing co-occuring mutations with several major driver mutations in PIK3CA using data from published cohorts and our medical center.
Dec 30, 2019 · Main signaling pathway initiated by growth factors that activate tyrosine kinase to initiate a series of downstream reactions that trigger P13K to generate second messenger (PIP3). PIP3 activates...
PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) is a gene that encodes the protein phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, a subunit of the PI3K protein.
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