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1. academic.oup.com › toxsci › articleParacelsus and Formaldehyde 2010: The Dose to the Target ...

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   Jun 28, 2010 · With environmental, dietary, and endogenous exposures to formaldehyde, epidemiological studies on formaldehyde are warranted, and the integration of basic mechanistic data with the epidemiological findings are critical to developing sound human cancer risk assessments for this high-volume chemical.

   • Author: Lois Lehman-McKeeman

   • Publish Year: 2010

2. academic.oup.com › toxsci › article-abstractThe dose disrupts the pathway: application of Paracelsus ...

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   May 7, 2024 · Application of Paracelsus’s principle to mechanistic toxicology may be challenging as one compound may affect many molecular pathways at different doses with different and often nonlinear dose-response relationships (DRR).

   • Author: Suvorov, Alexander

3. academic.oup.com › jhmas › article-abstractParacelsus: Medicine, Magic and Mission at the End of Time

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   Aug 7, 2009 · For Paracelsus his reformation of medicine paralleled the Church's Reformation, and even the societal revolution seemingly promised by the German Peasants' Revolt of 1525. Ever the independent thinker, Paracelsus developed an essentially unique religious position marked by elements of contemporary Anabaptism and Spiritualism.

   • Author: Joseph P. Byrne

   • Publish Year: 2010

4. www.sciencedirect.com › science › articleParacelsus to parascience: the environmental cancer distraction

   www.sciencedirect.com › science › article

   Jan 17, 2000 · High doses can cause chronic wounding of tissues, cell death and consequent chronic cell division of neighboring cells, which is a risk factor for cancer. Each time a cell divides, there is some probability that a mutation will occur, and thus increased cell division increases the risk of cancer.

   • Author: Bruce N Ames, Lois Swirsky Gold

   • Publish Year: 2000

5. jamanetwork.com › journals › jamaParacelsus: Medicine, Magic and Mission at the End of Time

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   Mar 25, 2009 · The Swiss-Austrian-German surgeon-alchemist-mystic Theophrastus von Hohenheim (1493-1541)—also known as Theophrastus Bombastus Aureolus von Hohenheim, or simply Paracelsus—is best known to medical history as a lone revolutionary.

   • Author: Christopher Hamlin

   • Publish Year: 2009

6. www.ncbi.nlm.nih.gov › pmc › articlesTheophrastus Bombastus Von Hohenheim (Paracelsus) (1493–1541 ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 23, 2021 · Introduction. The main purpose of this article is to highlight the great impact of Paracelsus, a German-Swiss alchemist and physician of the 16th century, on toxicology. Paracelsus is recognized as the most influential medical scientist in Western Europe during the Renaissance.

7. People also ask

   Why did Paracelsus claim the importance of dose?

   • Paracelsus was the first to claim the importance of dose in his Third Defence, which he wrote in response to those who criticized him for using toxic substances as therapies: “What is there that is not a poison? All things are poison, and nothing is without poison. Solely the dose determines that a thing is not a poison.”

   Theophrastus Bombastus Von Hohenheim (Paracelsus) (1493–1541): The

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   Why was Paracelsus important?

   • Paracelsus emphasized the importance of dosing in distinguishing between toxicity and treatment. Theophrastus Bombastus Von Hohenheim known as Paracelsus was a German-Swiss homo universalis, or Renaissance man, whose interests included medicine, chemistry and toxicology.

   Theophrastus Bombastus Von Hohenheim (Paracelsus) (1493–1541): The

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   What does Paracelsus say about toxicity?

   • All things are poison, and nothing is without poison. Solely the dose determines that a thing is not a poison.” Thus, Paracelsus emphasized the importance of dosing in distinguishing between toxicity and treatment [15, 18, , , , , ].

   Theophrastus Bombastus Von Hohenheim (Paracelsus) (1493–1541): The

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   How did Paracelsus interact with physicians and alchemists?

   • He interacted with physicians and alchemists from Spain to the Netherlands and Alexandria (Egypt). Paracelsus rejected Galen’s (129-c. 200) and Avicenna’s (980–1037) theories of medicine and pharmacopeia, which had prevailed for 15 centuries, and instead introduced the use of chemical substances, such as minerals, into medicine.

   Theophrastus Bombastus Von Hohenheim (Paracelsus) (1493–1541): The

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   What is a good introduction to Paracelsus?

   • As an introduction to Paracelsus, Ball's popularizing work is the better bet, as Webster assumes one knows Paracelsus, at least in outline, and is familiar with his historical background. Early on he sketches Paracelsus' life in a mere eleven pages.

   Paracelsus: Medicine, Magic and Mission at the End of Time

   academic.oup.com/jhmas/article-abstract/65/1/132/805241

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   Why did Paracelsus leave Basel?

   • Paracelsus was forced to leave Basel (Switzerland) in 1528 due to his rebellious character . He continued travelling around Europe and wrote several treatises, staying so busy that he did not learn of his father’s death until four years afterward. His most important book, The Great Surgery Book (Die Große Wundarzney) was published in 1536.

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8. core.ac.uk › download › pdfOncobiguanides: Paracelsus’ law and nonconventional routes ...

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   The so-called Paracelsus’ “dose-response effect” establishes that, for any drug, there is a dose range (concentration) that is without any effect, one with a pharmacological effect but minimal toxicity (or an acceptable safety profile), and another with pharmacological and toxic effects.