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Aug 12, 2020 · They can act as “killer cells”, attacking cells which have been infected with a virus or another kind of pathogen, or they can act as “helper cells” by supporting B cells to produce antibodies. What can T cells tell us about our immunity to COVID-19, and is this different from what an antibody test might reveal?
Jun 19, 2023 · T lymphocytes (T cells) are the major cell components of the adaptive immune system, responsible for mediating cell-based immune responses to keep the host healthy and prevent various types...
- Thymic Function
- T Cell Subclasses
- Advancing Research
While we now know the thymus is the site of T cell development, the general medical consensus in the 1950s was that the thymus was a vestigial organ without any direct immune function. In fact, a large thymus was presumed to be obstructive to breathing, and shrinking it by irradiation was recommended1. In an article published in 2004, Jacques Mille...
When Kohler and Milstein created monoclonal antibodies from hybridomas in 1975, it helped innumerable researchers to design antibodies against specific targets. Pairing new fluorophores with antibodies increased flow cytometry panel capabilities to phenotype T cells and their cytokine profile, revealing new subsets of T cells. BioLegend specializes...
Many researchers have turned to multiomics to find in-depth information on T cells. Our TotalSeq oligonucleotide antibody conjugates add protein detection to facilitate multiomic workflows by simultaneously analyzing genomic and protein content in a single cell. TotalSeq antibodies were used to analyze the immune response to COVID-19 infection4. In...
Feb 28, 2019 · Research has shown that changes to immune cells don’t need to be permanent. The theory is that if there’s a way to reverse these tricks, or stop immune cells falling for them, their cancer-fighting ability could be restored. This has formed the basis of a growing range of cancer treatments called immunotherapies.
Jan 27, 2023 · Poorly immunogenic tumors you couldn’t really immunize—even with kill tumor cells or lysates of tumor cells—you couldn’t even prophylactically immunize. For these, we tested combination therapies and could cure the cancer when combining anti-CTLA-4 with chemotherapy or radiation.
T cells are often found at the centre of the immune response to many diseases. Scientists who can understand and manipulate them stand a greater chance of creating life-altering treatments....
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Why do scientists need to understand and manipulate T cells?
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Can tumor-specific T cells be used to treat cancer?
Are killer T cells the key to cancer treatment?
Are T cells innate or adaptive?
Why are different sub-families of T cells important during infection?
Dec 13, 2021 · γδT cells have joined the “T cell arsenal” against cancer. Although their non-redundant role in tumor surveillance has been acknowledged for 20 years, only recently have the means to expand these rare cells to treat cancer patients been put in place.
