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Neuromodulation is the physiological process by which a given neuron uses one or more chemicals to regulate diverse populations of neurons. Neuromodulators typically bind to metabotropic, G-protein coupled receptors (GPCRs) to initiate a second messenger signaling cascade that induces a broad, long-lasting signal.
Neuromodulation refers to the process of using technology to impact the neural interface and modulate the function of the central, peripheral, or autonomic nervous systems. It involves the electrical or chemical stimulation, inhibition, modification, or regulation of neural activity for therapeutic purposes.
Jan 1, 2009 · The term neuromodulation can be defined as a technology that impacts upon neural interfaces and is the science of how electrical, chemical, and mechanical interventions can modulate or change central and peripheral nervous system functioning.
- Elliot S. Krames, P Hunter Peckham, Ali R. Rezai, Farag Aboelsaad
- 2009
Our discussion covers a breadth of modalities in neuromodulation, from electrical, thermal, and optical to pharmacological and multimodal combinations of these, in tissue-compliant and wireless platforms with demonstrated utility in animal model studies and clear promise in clinical translation.
Aug 16, 2023 · We first present a consensus definition of neuromodulation. We then describe a classification scheme based on the 1) intended use (the site of modulation and its indications) and 2) physical properties (waveforms and dose) of a neuromodulation therapy.
A seemingly straightforward definition is: Neuromodulation occurs when a substance released from one neuron alters the cellular or synaptic properties of another neuron (Kupfermann 1979 ; Kaczmarek and Levitan 1987 ).
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May 26, 2021 · Neuromodulators trigger second messenger cascades that affect neural circuits in two broad ways: (1) changing the excitability or temporal pattern of neuron activity and (2) altering the strength of synaptic connections between neurons (Marder and Bucher 2001; Dickinson 2006).
