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Our discussion covers a breadth of modalities in neuromodulation, from electrical, thermal, and optical to pharmacological and multimodal combinations of these, in tissue-compliant and wireless platforms with demonstrated utility in animal model studies and clear promise in clinical translation.
- Sang Min Won, Enming Song, Enming Song, Jonathan T. Reeder, John A. Rogers
- 2020
Jul 14, 2014 · This paper reviews the state-of-the-art in ENS as well as alternative neuromodulation techniques—presenting the operational concepts, technical implementation and limitations—in order to inform system design choices.
This article introduces two clinical fields in which stimulation is applied to the nervous system: neuromodulation and functional electrical stimulation. The concepts underlying these fields and their main clinical applications, as well as the methods and techniques used in each field, are described.
Mar 3, 2022 · These examples illustrate the ability of neuromodulation therapies to adjust stimulation dynamically. Responsive neuromodulation is also an area of active research and development. Clinical trials are underway to adapt DBS systems to respond to changes in electrophysiological signals.
Jan 4, 2017 · Nature Reviews Materials - Understanding the dynamics and architecture of the nervous system requires tools for recording and modulating the activity of billions of neurons. This Review...
May 26, 2021 · Neuromodulators trigger second messenger cascades that affect neural circuits in two broad ways: (1) changing the excitability or temporal pattern of neuron activity and (2) altering the strength of synaptic connections between neurons (Marder and Bucher 2001; Dickinson 2006).
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Neuromodulation refers to the process of using technology to impact the neural interface and modulate the function of the central, peripheral, or autonomic nervous systems. It involves the electrical or chemical stimulation, inhibition, modification, or regulation of neural activity for therapeutic purposes.
