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Apr 12, 2024 · Chemicals play an important role in neurophysiological and neuropathological processes. By regulating the concentration of specific chemicals applied, receptors on the neuron cell membrane can be modulated to activate or inhibit, thereby affecting specific ion channels and acheving neuromodulation.
Our discussion covers a breadth of modalities in neuromodulation, from electrical, thermal, and optical to pharmacological and multimodal combinations of these, in tissue-compliant and wireless platforms with demonstrated utility in animal model studies and clear promise in clinical translation.
- Sang Min Won, Enming Song, Enming Song, Jonathan T. Reeder, John A. Rogers
- 2020
Neuromodulation is the physiological process by which a given neuron uses one or more chemicals to regulate diverse populations of neurons. Neuromodulators typically bind to metabotropic, G-protein coupled receptors (GPCRs) to initiate a second messenger signaling cascade that induces a broad, long-lasting signal.
Jan 4, 2017 · Understanding the dynamics and architecture of the nervous system requires tools for recording and modulating the activity of billions of neurons. This Review explores the history of neural...
Dec 1, 2014 · The divergent and convergent neuromodulator actions can be unambiguously synergistic or antagonistic, but neuromodulation often entails balanced adjustment of nonlinear membrane and synaptic properties by targeting ion channel and synaptic dynamics rather than just excitability or synaptic strength.
Aug 1, 2019 · Rather than pharmacological modulation of diseases, bioelectronic medicine uses electrical control of the nervous system to ameliorate symptoms by targeting the dysfunctional neural activity responsible for exacerbating the disease pathology.
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Neuromodulation is a bold and “heady” concept. It is one thing to interact with the nervous system by making a lesion to mitigate the effects of a seizure focus, for example – or even to place an electrode with a stimulation effect that mimics a carefully placed lesion.
