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Neuromodulation is the physiological process by which a given neuron uses one or more chemicals to regulate diverse populations of neurons. Neuromodulators typically bind to metabotropic, G-protein coupled receptors (GPCRs) to initiate a second messenger signaling cascade that induces a broad, long-lasting signal.
Apr 12, 2024 · Chemicals play an important role in neurophysiological and neuropathological processes. By regulating the concentration of specific chemicals applied, receptors on the neuron cell membrane can be modulated to activate or inhibit, thereby affecting specific ion channels and acheving neuromodulation.
Our discussion covers a breadth of modalities in neuromodulation, from electrical, thermal, and optical to pharmacological and multimodal combinations of these, in tissue-compliant and wireless platforms with demonstrated utility in animal model studies and clear promise in clinical translation.
Jan 1, 2009 · The INS (the International Neuromodulation Society) defines neuromodulation as a field of science, medicine, and bioengineering that encompasses implantable and nonimplantable technologies, electrical or chemical, for the purpose of improving quality of life and functioning of humans.
- Elliot S. Krames, P Hunter Peckham, Ali R. Rezai, Farag Aboelsaad
- 2009
Aug 16, 2023 · We first present a consensus definition of neuromodulation. We then describe a classification scheme based on the 1) intended use (the site of modulation and its indications) and 2) physical properties (waveforms and dose) of a neuromodulation therapy.
A seemingly straightforward definition is: Neuromodulation occurs when a substance released from one neuron alters the cellular or synaptic properties of another neuron (Kupfermann 1979 ; Kaczmarek and Levitan 1987 ).
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Neuromodulation is defined by the International Neuromodulation Society as a field of science, medicine, and bioengineering that encompasses implantable and nonimplantable technologies, electrical or chemical, that have an impact on neural interfaces to improve life for humanity.
