Search results
May 26, 2021 · Neuromodulators trigger second messenger cascades that affect neural circuits in two broad ways: (1) changing the excitability or temporal pattern of neuron activity and (2) altering the strength of synaptic connections between neurons (Marder and Bucher 2001; Dickinson 2006).
- Charlotte L Barkan, Elizabeth C Leininger, Erik Zornik
- 2021
Neuromodulation is the physiological process by which a given neuron uses one or more chemicals to regulate diverse populations of neurons. Neuromodulators typically bind to metabotropic, G-protein coupled receptors (GPCRs) to initiate a second messenger signaling cascade that induces a broad, long-lasting signal.
Our discussion covers a breadth of modalities in neuromodulation, from electrical, thermal, and optical to pharmacological and multimodal combinations of these, in tissue-compliant and wireless platforms with demonstrated utility in animal model studies and clear promise in clinical translation.
- Sang Min Won, Enming Song, Enming Song, Jonathan T. Reeder, John A. Rogers
- 2020
Dec 1, 2014 · The divergent and convergent neuromodulator actions can be unambiguously synergistic or antagonistic, but neuromodulation often entails balanced adjustment of nonlinear membrane and synaptic properties by targeting ion channel and synaptic dynamics rather than just excitability or synaptic strength.
Jun 16, 2021 · One such example occurs in the context of a model of renewal control in stem cells (Buzi et al., 2015). In this system, feedback from a differentiated population acts upon the stem or progenitor cell to affect its probability of regeneration.
- Hana El-Samad, Hana El-Samad
- 2021
Examples of approaches intended to overcome foreign-body response and increase the resolution of neural interfaces. a│ Use of flexible substrates and modulus-matching coatings to reduce elastic mismatch between the neural probes and neural tissues.
People also ask
What is modulation & how does it work?
What modalities are used in neuromodulation?
How does a neuromodulation platform work?
How do modulators affect neuronal excitability?
Why is Neuromodulation important?
Can neuromodulation be used in animal models?
Dec 6, 2016 · Despite this diversity, five elements are recognized as critical for generating or modulating temporal or spatial oscillatory dynamics: negative feedback, time delay, positive feedback,...
