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May 26, 2021 · Neuromodulators trigger second messenger cascades that affect neural circuits in two broad ways: (1) changing the excitability or temporal pattern of neuron activity and (2) altering the strength of synaptic connections between neurons (Marder and Bucher 2001; Dickinson 2006).
- Charlotte L Barkan, Elizabeth C Leininger, Erik Zornik
- 2021
Our discussion covers a breadth of modalities in neuromodulation, from electrical, thermal, and optical to pharmacological and multimodal combinations of these, in tissue-compliant and wireless platforms with demonstrated utility in animal model studies and clear promise in clinical translation.
- Sang Min Won, Enming Song, Enming Song, Jonathan T. Reeder, John A. Rogers
- 2020
Jun 16, 2021 · For example, by adding feedback to guard an important cellular output against a fluctuating environment, the cell lands at a new meager or toxic steady state of that output as collateral damage, and then, the next loop would form to alleviate this problem, creating yet another hard wall to hit.
- Hana El-Samad, Hana El-Samad
- 2021
Neuromodulation is the physiological process by which a given neuron uses one or more chemicals to regulate diverse populations of neurons. Neuromodulators typically bind to metabotropic, G-protein coupled receptors (GPCRs) to initiate a second messenger signaling cascade that induces a broad, long-lasting signal.
Dec 1, 2014 · The divergent and convergent neuromodulator actions can be unambiguously synergistic or antagonistic, but neuromodulation often entails balanced adjustment of nonlinear membrane and synaptic properties by targeting ion channel and synaptic dynamics rather than just excitability or synaptic strength.
Examples of approaches intended to overcome foreign-body response and increase the resolution of neural interfaces. a│ Use of flexible substrates and modulus-matching coatings to reduce elastic mismatch between the neural probes and neural tissues.
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Sep 2, 2024 · The extracellular matrix (ECM) is a scaffold that supports cell structure and function. This Review discusses the compositional diversity, tissue-specific assembly and remodelling of the ECM in...
