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1. en.wikipedia.org › wiki › ExposomeExposome - Wikipedia

   en.wikipedia.org › wiki › Exposome

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   The exposome is a concept used to describe environmental exposures that an individual encounters throughout life, and how these exposures impact biology and health. It encompasses both external and internal factors, including chemical, physical, biological, and social factors that may influence human health.

2. www.nature.com › articles › s41540/018/0065-0Redefining environmental exposure for disease etiology | npj ...

   www.nature.com › articles › s41540/018/0065-0

   Sep 1, 2018 · Etiological studies of human exposures to environmental factors typically rely on low-throughput methods that target only a few hundred chemicals or mixtures. In this Perspectives article, I ...

   • Author: Stephen M Rappaport
   • Email: srappaport@berkeley.edu

   • Publish Year: 2018

3. ehp.niehs.nih.gov › doi › fullThe Importance of the Biological Impact of Exposure to the ...

   ehp.niehs.nih.gov › doi › full

   Biological fluids (i.e., blood, serum, plasma) and excreta (i.e., saliva, feces, urine) collected with minimally invasive methods are ideal for sampling in clinical and epidemiological investigations aimed at understanding how the environment perturbs molecular, microbial, and biochemical pathways.

   • Author: Kristine K. Dennis, Scott S. Auerbach, David M. Balshaw, Yuxia Cui, Margaret Daniele Fallin, Martyn ...

   • Publish Year: 2016

4. www.science.org › doi › 10The exposome and health: Where chemistry meets biology

   www.science.org › doi › 10

   Jan 24, 2020 · The “exposome” concept strives to capture the diversity and range of exposures to synthetic chemicals, dietary constituents, psychosocial stressors, and physical factors, as well as their corresponding biological responses.

   • Author: Roel Vermeulen, Emma L. Schymanski, Albert-László Barabási, Albert-László Barabási, Albert-László Ba...

   • Publish Year: 2020

5. www.niehs.nih.gov › research › supportedExposure Biology and the Exposome - National Institute of ...

   www.niehs.nih.gov › research › supported

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   NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health.

6. www.ncbi.nlm.nih.gov › pmc › articlesEnvironment, susceptibility windows, development and child ...

   www.ncbi.nlm.nih.gov › pmc › articles

   The nature of the long term health impact of an exposure is dependent not only on dose, but also on the timing of exposure. Advances in exposure science, toxicology and biostatistics will create new opportunities to identify and better define windows of susceptibility to environmental exposures.

7. People also ask

   What is a 'exposome'?

   • In contrasting the rich science spawned by the human genome project with the fragmented efforts to characterize environmental exposures, Christopher Wild defined the ‘‘exposome’’, representing the totality of exposures from conception onwards, as a quantity of critical interest for understanding the environmental causes of disease (Wild, 2005).

   Implications of the exposome for exposure science

   www.nature.com/articles/jes201050

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   What is an exposome & why is it important?

   • The exposome is a concept used to describe environmental exposures that an individual encounters throughout life, and how these exposures impact biology and health. It encompasses both external and internal factors, including chemical, physical, biological, and social factors that may influence human health.

   Exposome - Wikipedia

   en.wikipedia.org/wiki/Exposome

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   How do exposure scientists characterize exposomes?

   • Exposure scientists can adopt either ‘‘bottom-up’’ or ‘‘top-down’’ strategies for characterizing exposomes, (Rappaport and Smith, 2010). As shown in Figure 2 (left), a bottom-up strategy would involve sampling of air, water and dietary sources of exposure, followed by quantitation of chemicals in these samples.

   Implications of the exposome for exposure science

   www.nature.com/articles/jes201050

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   Is biological impact outside the concept of the exposome?

   • The ability to respond in a resilient manner also impacts the biology of an individual. The biological impact could be considered to be outside the concept of the exposome if one takes the view that the exposome is exclusively focused on the chemical exposures and processes.

   The Importance of the Biological Impact of Exposure to the

   ehp.niehs.nih.gov/doi/full/10.1289/EHP140

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   What is the relationship between the exposome and biology?

   • The exposome and biology are interactive—changes in biology due to the environment change one’s vulnerability to subsequent exposures. Additionally, highly resilient individuals are able to withstand environmental exposures with minimal effects to their health.

   The Importance of the Biological Impact of Exposure to the

   ehp.niehs.nih.gov/doi/full/10.1289/EHP140

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   How can environmental exposure be defined by the blood exposome?

   • In this Perspectives article, I outline how environmental exposure can be defined by the blood exposome—the totality of chemicals circulating in blood. The blood exposome consists of chemicals derived from both endogenous and exogenous sources.

   Redefining environmental exposure for disease etiology

   www.nature.com/articles/s41540-018-0065-0

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8. www.nature.com › articles › jes201050Implications of the exposome for exposure science | Journal ...

   www.nature.com › articles › jes201050

   Nov 17, 2010 · The concept of the exposome, representing the totality of exposures received by a person during life, encompasses all sources of toxicants and, therefore, offers scientists an agnostic approach...