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  2. Sep 30, 2010 · Familial Mediterranean fever is primarily a genetic disease due to Mendelian-recessive inheritance of Mediterranean fever gene mutations. Occurs mainly in people of Mediterranean ancestry, especially from Arab countries, Turkey, Israel, and Armenia. Characterised by recurrent attacks of fever and...

    • Summary

      Familial Mediterranean fever (FMF; phenotype Mendelian...

    • Complications

      Complications - Familial Mediterranean fever - Symptoms,...

    • Criteria

      Criteria - Familial Mediterranean fever - Symptoms,...

    • Guidelines

      Guidelines - Familial Mediterranean fever - Symptoms,...

    • Investigations

      Investigations - Familial Mediterranean fever - Symptoms,...

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      Screening - Familial Mediterranean fever - Symptoms,...

  3. M04.1 is a billable diagnosis code used to specify periodic fever syndromes. Synonyms: amyloid of familial mediterranean fever, aphthous ulcer of mouth, cervical

  4. Oct 1, 2016 · M04.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM M04.1 became effective on October 1, 2024. This is the American ICD-10-CM version of M04.1 - other international versions of ICD-10 M04.1 may differ.

    • What Is Familial Mediterranean Fever?
    • Who Gets Familial Mediterranean Fever and Why?
    • What Are The Clinical Features of Familial Mediterranean Fever?
    • What Triggers Attacks?
    • How Is Familial Mediterranean Fever Diagnosed?
    • Investigations in Familial Mediterranean Fever
    • What Is The Treatment of Familial Mediterranean Fever?

    Familial Mediterranean fever is an inherited autoinflammatory syndrome characterised by recurrent short episodes of high fever associated with abdominal pain, inflammation of joints and other body sites and skin rash. If untreated, amyloidosis commonly develops and may have a fatal outcome. Familial Mediterranean fever is the most common of the per...

    Familial Mediterranean fever mainly affects specific racial groups originating from around the eastern Mediterranean Sea. These include: 1. Arabs 2. Armenians 3. Italians (mild form) 4. Jews 5. Turks. In these groups, 1 in 25 to 1 in 2000 people are affected. By comparison, in west Europeans, the prevalence is 2.5 per 100,000 (1 in 40,000) people. ...

    The most common clinical features of familial Mediterranean fever are: 1. febrile attacks lasting for 1-3 days 2. severe abdominal, chest and/or joint pain 3. erysipelas-like changes on the lower legs. Onset is almost always before 30 years of age. Children under the age of 2 years often present with fever alone, and progressto more typical attacks...

    The frequency of episodes is variable, ranging from weekly to every few years. Attacks may be triggered by: 1. Exercise 2. Infection 3. Menstruation 4. Stress. Acute attacks settle spontaneously. Between episodes, health is normal.

    Diagnosis of familial Mediterranean fever is made using the Tel-Hashomer criteria: 1. The diagnosis if definite if 2 major or 1 major + 2 minor criteria are met. 2. The diagnosis is probable if 1 major + 1 minor criteria are met.

    Blood tests during an attack may show: 1. Increased white blood cell count (leukocytosis), erythrocyte sedimentation rate (ESR), serum fibrinogen, C-reactive protein (CRP) 2. Increased serum IgD in 10%. X-rays of the abdomen often reveal multiple fluid levels suggesting an ‘acute abdomen’ A skin biopsy from the erysipelas-like lesion may show a hea...

    Colchicine, taken orally each day for life, is the drug of choice for familial Mediterranean fever to: 1. reduce the frequency of attacks 2. reduce the severity of attacks 3. prevent secondary systemicamyloidosis. Colchicine is potentially toxicso it is very important not to take an excessive dose. The dose of colchicine is increased stepwise up to...

  5. Disease definition. Familial Mediterranean fever (FMF) is an autoinflammatory disorder characterized by recurrent short episodes of fever and serositis resulting in pain in the abdomen, chest, joints and muscles. ORPHA:342. Classification level: Disorder. Synonym (s): Benign paroxysmal peritonitis. Benign recurrent polyserositis. FMF.

  6. Familial Mediterranean fever is an autosomal recessive disorder characterized by recurrent bouts of fever and peritonitis , sometimes with pleuritis, skin lesions, arthritis, and, rarely, pericarditis. Renal amyloidosis may develop, sometimes leading to renal failure.

  7. Familial Mediterranean fever (FMF) is a disease of people with genetic origins in the Mediterranean basin, predominantly people who have Sephardic Jewish, North African Arab, Armenian, Turkish, Greek, or Italian ancestry.

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