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  1. Nov 11, 2021 · Arthritic attacks may last for weeks or months. Signs and symptoms of FMF attacks vary, but can include: Fever. Abdominal pain. Chest pain, which can make it hard to breathe deeply. Painful, swollen joints, usually in the knees, ankles and hips. A red rash on your legs, especially below your knees. Muscle aches. A swollen, tender scrotum.

  2. Oct 1, 2016 · Periodic fever syndromes. M04.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2024 edition of ICD-10-CM M04.1 became effective on October 1, 2023. This is the American ICD-10-CM version of M04.1 - other international versions of ICD-10 M04.1 may differ.

  3. Familial Mediterranean fever ( FMF) is a hereditary inflammatory disorder. [1] : 149 FMF is an autoinflammatory disease caused by mutations in Mediterranean fever gene, which encodes a 781–amino acid protein called pyrin. [2] While all ethnic groups are susceptible to FMF, it usually occurs in people of Mediterranean origin—including ...

  4. Aug 31, 2022 · Definition. Familial Mediterranean fever (FMF; phenotype Mendelian Inheritance in Man number 249100) is part of the currently expanding family of auto-inflammatory disorders.The disease originated over 2000 years ago in western Asia and spread to the Mediterranean basin and the rest of the globe with the advent of extensive global migration.

  5. Molecular biology and genetics. Familial Mediterranean fever is usually due to mutations in the Mediterranean fever ( MEFV) or pyrin gene located on chromosome 16 (16p13.3). Mutations in the MEFV gene have been found in 80% of typical cases. More than 100 different disease-linked mutations have been identified.

  6. FMF can be divided into 2 types: FMF type 1 and 2. Type 1 is characterized by attacks (as often as once a week or every few years) of fever and serositis lasting 1-4 days and resolving spontaneously. Stress, exposure to cold, fat-rich meals, infections, certain drugs and menstrual cycles are possible attack triggers.

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  8. Nov 11, 2021 · Tests and procedures used to diagnose familial Mediterranean fever include: Physical exam. Your health care provider may ask you about your signs and symptoms and do a physical exam to gather more information. Review of your family medical history. A family history of Familial Mediterranean fever (FMF) increases your likelihood of developing ...

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