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Feb 6, 2024 · The most common side effects for all four drugs include: Nausea. Vomiting. Diarrhea. Constipation. Heartburn and acid reflux (including burping). Bloating. “We’ve seen people have tolerance ...
- Stacey Colino
- Contributor
Wegovy comes as a pre-filled injector pen. You can use it to inject yourself weekly, under the skin in the upper arms, stomach, thighs or buttocks. Wegovy is one of two weight loss injections available on the NHS, the other being Saxenda (liraglutide). In July 2024, Wegovy was also approved to help lower the risk of heart attack and stroke in ...
If you take Mounjaro with other type 2 diabetes medications that lower your blood sugar (insulin, sulphonylureas), this can increase your risk of getting low blood sugar. Symptoms of low blood sugar include: feeling dizzy. feeling tired. feeling hungry. weakness. confusion. irritability. anxiety.
- Overview
- What are the risks of drugs like Ozempic in older adults?
- What the experts think about using GLP-1 drugs
- Other effective alternatives to GLP-1 drugs
- Takeaway
•GLP-1 drugs like Ozempic have become quite popular, especially as weight-loss aids.
•However, they do have certain drawbacks, like rebound weight gain and loose skin.
•Not much is known about their side effects in older people.
•However, people over 65 tend to be more prone to drug side effects in general.
•Experts say, with proper supervision, these drugs are “truly remarkable” in this population.
GLP-1 drugs include the various brands of semaglutide (Ozempic, Rybelsus, Wegovy) as well as dulaglutide (Trulicity), exenatide (Bydureon, Byetta), liraglutide (Victoza, Saxenda), lixisenatide (Adlyxin), and tirzepatide (Mounjaro).
Dina Peralta-Reich, M.D., FAAP, FOMA, and Director of New York Weight Wellness Medicine, says a potential risk that is associated with these medications in people over the age of 65 is dehydration.
“Monitoring water intake can be challenging, and it is crucial to avoid dehydration, which may result in dizziness, falls, fainting, and possibly fractures,” she said.
Additionally, she said that the gastrointestinal side effects of these medications, like nausea and vomiting, may be worse in older people, which “may set them up for dehydration, weakness, or nutritional deficiencies.”
Peralta-Reich further advised that anyone using these medications should be supervised by a specialist. “As an obesity medicine specialist, our primary objective is to ensure successful weight loss while also safeguarding against the loss of muscle mass,” she explained.
Jill Barat, Pharm.D., a licensed pharmacist with Pharmedico Pharmacy, added, “Muscle loss isn’t a good thing for anyone, but this can be especially dangerous for older people as it may put them at higher risk of falls which can lead to broken bones.”
Peralta-Reich suggests that close monitoring is important for older patients — especially if they have other health conditions, such as high blood pressure, diabetes, and hormonal deficiencies — since dosage may change over the course of treatment.
Peralta-Reich commented that she feels these drugs are “truly remarkable,” provided the patient has oversight from a board-certified obesity medicine specialist.
“Regardless of age, the risks associated with being overweight or obese remain significant,” she said. “By effectively reducing body fat percentage and visceral fat, people can substantially lower the chances of developing other comorbidities.”
Dr. Michael Russo, a Bariatric Surgeon at Smart Dimensions in Orange County, California, cautioned, however, that drugs like Ozempic are not a quick fix.
“This medication needs to be coupled with lifestyle changes in order to not only get the best results but to minimize the chance of weight regain in the future,” he advised.
As a word of encouragement, Peralta-Reich noted that the age of 65 is no longer considered to be old. “[I]t presents an excellent opportunity to take charge of one’s health and weight in a safe and effective manner,” she said.
“Embracing a healthier lifestyle can lead to positive outcomes at any age!”
It should be noted, however, that drugs like Ozempic are not always available to patients due to their expense and the fact that many insurance companies are not opting to cover them, especially for weight loss.
When it comes to the management of Type 2 diabetes, Dr. Kezia Joy, Medical Content Advisor for Welzo, said there are several alternatives to the GLP-1 drugs, including:
•Metformin
•DPP-4 inhibitors
•SGLT2 inhibitors
•Insulin therapy
GLP-1 drugs like Ozempic have become quite popular, especially as weight-loss aids. However, they do have certain drawbacks, like rebound weight gain and loose skin.
Not much is known about their side effects in older people. However, people over 65 tend to be more prone to drug side effects in general.
Aug 3, 2023 · In fact, a 2021 phase 3 clinical trial found that 2.4 milligram weekly semaglutide injections produced a mean weight loss of 14.9% (versus 2.4% with a placebo) after 68 weeks in people with a body ...
Mar 31, 2021 · Results revealed that compared with baseline (mean TSH=4.84 [1.29] μIU/mL), participants on LT3 and LT4 had an average weight loss of 2.5 kg (P <.001) and 1.1 kg (P <.02). Participants on LT3 experienced a decrease in fat mass by an average of 1.5 kg (P <.01 vs baseline) while those on LT4 experienced a decrease of 0.7 kg (P =.03 vs baseline ...
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May 17, 2024 · Common GLP-1 side effects include abdominal pain, nausea, vomiting, and diarrhea. [1] [16] These usually dissipate after a few days or weeks, but they can still be problematic, especially for ...
