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1. pn.bmj.com › content › 22/1/32Huntington’s disease: diagnosis and management | Practical ...

   pn.bmj.com › content › 22/1/32

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   Huntington’s disease (HD) is an inherited neurodegenerative disease characterised by neuropsychiatric symptoms, a movement disorder (most commonly choreiform) and progressive cognitive impairment. The diagnosis is usually confirmed through identification of an increased CAG repeat length in the huntingtin gene in a patient with clinical ...

2. onlinelibrary.wiley.com › doi › fullHuntington's disease: a clinical review - McColgan - 2018 ...

   onlinelibrary.wiley.com › doi › full

   Aug 17, 2017 · Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on chromosome 4. In Western popul...

   • Author: Peter McColgan, Sarah J Tabrizi

   • Publish Year: 2018

3. www.nature.com › articles › nrdp20155Huntington disease - Nature Reviews Disease Primers

   www.nature.com › articles › nrdp20155

   Apr 23, 2015 · Huntington disease is endemic to all populations but occurs at much higher frequencies among individuals of European ancestry. In Japan, Hong Kong and Taiwan, Huntington disease is diagnosed in...

4. www.ucl.ac.uk › huntingtons-disease-centreHuntington's Disease Centre | UCL Queen Square Institute of ...

   www.ucl.ac.uk › huntingtons-disease-centre

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   Our vision is a world in which Huntington’s disease is no longer something families have to worry about. The UCL Huntington’s disease centre strives to achieve this future by combining world-class scientific expertise and the highest quality multidisciplinary clinical care.

5. www.huntingtonhealth.org › in-the-news › huntingtonHuntington Health, an affiliate of Cedars-Sinai, welcomes ...

   www.huntingtonhealth.org › in-the-news › huntington

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   Aug 23, 2023 · Eight expert surgeons have recently joined the Cardiac, Vascular and Thoracic Surgery Program at Huntington Health, an affiliate of Cedars-Sinai, to offer a wide range of lifesaving and life-enhancing surgeries to local patients.

6. movementdisorders.onlinelibrary.wiley.com › doiA MDS Evidence-Based Review on Treatments for Huntington’s ...

   movementdisorders.onlinelibrary.wiley.com › doi

   Nov 29, 2021 · There was no eligible evidence to support the use of specic treatments for depression, psychosis, fi. irritability, apathy, or suicidality. Similarly, no evidence was eligible to support the use of physiotherapy, occu-pational therapy, exercise, dietary, or surgical treatments.

7. People also ask

   What is the most pressing unmet need in Huntington disease?

   • The most pressing unmet need in Huntington disease is for a therapeutic that shows evidence of disease modification — slowing, preventing or even reversing the disease in mutation carriers.

   Huntington disease - Nature Reviews Disease Primers

   www.nature.com/articles/nrdp20155

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   Is a polymorphic DNA marker genetically linked to Huntington's disease?

   • A polymorphic DNA marker genetically linked toHuntington’s disease. Nature 1983;306(5940):234–238. The Huntington’s Disease Collaborative Research Group. A novelgene containing a trinucleotide repeat that is expanded and unstableon Huntington’s disease chromosomes. Cell 1993;72(6):971–983.

   An MDS Evidence‐Based Review on Treatments for Huntington's Disease

   movementdisorders.onlinelibrary.wiley.com/doi/epdf/10.1002/mds.28855

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   What is Huntington's Disease Research?

   • Our research spans the full range from laboratory research to understand how the Huntington’s disease gene causes the disease and how it affects the living human brain, through to the development of innovative new treatments and leading the world in clinical trial design and execution.

   Huntington's Disease Centre | UCL Queen Square Institute of Neurology

   www.ucl.ac.uk/ion/research/research-centres/huntingtons-disease-centre

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   How does Huntington disease affect Qol?

   • Overall, the impact of Huntington disease on QOL in affected families changes over the lifetime of the affected individuals. Psychosocial issues dominate early in the life of an at-risk individual, and cognitive and behavioural issues during the prodromal and early symptomatic stages of the disease.

   Huntington disease - Nature Reviews Disease Primers

   www.nature.com/articles/nrdp20155

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   What causes Huntington disease?

   • Huntington disease is caused by an expanded CAG trinucleotide repeat in HTT 5, which identifies the pathogenetic agent — a mutant form of the multifunctional protein huntingtin.

   Huntington disease - Nature Reviews Disease Primers

   www.nature.com/articles/nrdp20155

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   Do HTT haplotypes contribute to differences in Huntington disease prevalence?

   • Warby, S. C. et al. HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia. Eur. J. Hum. Genet. 19, 561–566 (2011). Baine, F. K. et al. Huntington disease in the South African population occurs on diverse and ethnically distinct genetic haplotypes. Eur. J. Hum. Genet. 21, 1120–1127 (2013).

   Huntington disease - Nature Reviews Disease Primers

   www.nature.com/articles/nrdp20155

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8. www.frontiersin.org › journals › psychiatryImproving Mood and Cognitive Symptoms in Huntington's Disease ...

   www.frontiersin.org › journals › psychiatry

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   Feb 9, 2022 · In Huntington's disease (HD), the main clinical symptoms include depression, apathy, cognitive deficits, motor deficiencies and involuntary movements. Cognitive, mood and behavioral changes may precede motor symptoms by up to 15 years.