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Jul 6, 2023 · To the simplest definition of cancer as a disease of uncontrolled proliferation of cells, our definition adds in the adjective "transformed" to capture the many tumorigenic processes that...
Jul 23, 2023 · Cancer is an illness wherein cells multiply and grow abnormally, invading other tissues and organs via the bloodstream and lymphatic systems (Thiagalingam, 2015). The human body contains trillions of cells, and cancer can manifest itself practically anywhere in the...
Define neoplasm. Define benign and malignant. Differentiate benign from malignant neoplasms based on histologic appearance. Explain how neoplasms are named and infer properties of a neoplasm from its name. Explain what grade is, and how it impacts prognosis.
Introduction to Cancer Biology. From basic principles to insights into pioneering research, this introductory textbook provides the fundamentals of cancer biology that will enable students of biology and medicine to enter the field with confidence.
What is Cancer?1. Cancer is a collection of related diseases where some cells divide without stopping and spread into surrounding tissues. Cancer can start almost anywhere in the body. Normally, our cells grow and divide to form new cells as our body needs them. When cells grow old or become damaged, they die, and new cells take their place.
An invasive tumor is said to be malignant, and cells shed into the blood or lymph from a malignant tumor are likely to establish new tumors (metastases) throughout the body. Tumors threaten an individual's life when their growth disrupts the tissues and organs needed for survival.
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- A Concise Journey from Epidemiology through Cell and Molecular Biology to Treatment and Prospects
- 1 Lessons from epidemiology
- 2 Causes of cancer
- 3 Signalling in normal cells
- 5 What is a tumour?
- ACKNOWLEDGEMENTS
- INTRODUCTION
This concise overview of the fundamental concepts of cancer biology is ideal for those with little or no background in the field. A summary of global cancer patterns introduces students to the general principles of how cancers arise and the risk factors involved. By focusing on fundamental examples of the signalling pathways within cells, the funct...
Incidence Deaths Patterns around the world: how many cancers and what sort? Trends Age Where do we stand and is there any good news? Conclusions Key points Future directions Further reading: reviews
Introduction Infection Radiation Ionising radiation Radon Ultraviolet radiation Low-frequency magnetic fields High-frequency magnetic fields (mobile phones) Tobacco Alcohol Tea and coffee Diet: epidemiological studies Obesity Stress
Introduction Enzyme-coupled receptors Receptor tyrosine kinases (RTKs) Intracellular signalling from activated tyrosine kinase receptors Activating RAS and MAPK Sustained versus transient activation of RAS and MAPK Mitogenic activation of cell cycle progression MYC is a central regulator of cell growth and proliferation MYC and proliferation Cytoki...
Introduction Benign tumours The benign–malignant boundary Types of malignant (non-benign) cancer What makes a cancer cell a cancer cell? Cancer cell characteristics Cell growth is largely independent of normal signals Resistance to inhibitory growth signals Resistance to cell death Unlimited replicative capacity Induction of angiogenesis Abnormal m...
No cancer book should fail to acknowledge the vast, anonymous army of those who have confronted cancer and in so doing found the resolution to participate in medical research. Over the years they have made an immense contribution to our knowledge of cancer and, as we move into the era of personal genome sequencing, their role has become even more s...
The aim of this book is to provide an introduction to the science of cancer for those coming to the topic for the first time – be they students or graduates or post-doctoral scientists moving into the field of oncology. That is, to paint a picture of what we think happens to cells and molecules in the making of cancers, how it bears on diagnosis an...
