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   Can gout be treated with febuxostat or allopurinol?

   • People without a major cardiovascular disease can be offered either allopurinol or febuxostat as first line treatment. Gout is a painful and debilitating condition with long term complications, including joint damage and renal stones.

   Gout: diagnosis and management—summary of NICE guidance

   www.bmj.com/content/378/bmj.o1754

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   Can painkillers help gout?

   • Gout is a type of arthritis that causes sudden, severe joint pain. Painkillers can help the pain and healthier lifestyle choices can prevent future attacks. The main symptoms of gout are: hot, swollen, red skin over the affected joint – redness may be harder to see on black or brown skin.

   Gout - NHS

   www.nhs.uk/conditions/gout/

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   What is the treatment for acute gout?

   • Combination treatment can be considered for acute attacks of gout in patients with an inadequate response to monotherapy. An interleukin-1 inhibitor can be considered for the treatment of acute attacks of gout in patients in whom NSAIDs, colchicine, and corticosteroids are unsuitable or ineffective (under specialist guidance).

   Gout | Treatment summaries | BNF | NICE

   bnf.nice.org.uk/treatment-summaries/gout/

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   Can a proton pump inhibitor be used for gout?

   • Consider the need to prescribe a proton pump inhibitor (PPI) for gastric protection. For more information, see the CKS topic on NSAIDs - prescribing issues. Note: aspirin is not indicated for gout. Colchicine. A short course of oral corticosteroid — for example prednisolone 30-35 mg once a day for 3-5 days.

   Scenario: Acute gout | Management - CKS | NICE

   cks.nice.org.uk/topics/gout/management/acute-gout/

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   Who should be treated for gout?

   • All patients with gout should be offered urate-lowering therapy, particularly those with multiple or troublesome acute attacks, chronic gouty arthritis, chronic kidney disease stages 3 to 5, large crystal deposits (tophi), or those on diuretic therapy.

   Gout | Treatment summaries | BNF | NICE

   bnf.nice.org.uk/treatment-summaries/gout/

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   Can gout flare up after taking allopurinol?

   • Thyroid stimulating hormone level increases. Gout flares — there is a risk of precipitating acute attacks of gout after starting allopurinol. Advise people who experience acute attacks of gout after initiation of treatment with allopurinol, or during established treatment, to continue taking allopurinol. Hypersensitivity.

   Allopurinol | Prescribing information | Gout | CKS - NICE

   cks.nice.org.uk/topics/gout/prescribing-information/allopurinol/

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2. www.nhs.uk › medicines › allopurinolAllopurinol: a medicine to treat gout - NHS

   www.nhs.uk › medicines › allopurinol

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   Find out how allopurinol treats gout and how to take it. About allopurinol. Who can and cannot take it. How and when to take it. Side effects. Pregnancy, breastfeeding and fertility. Taking allopurinol with other medicines and herbal supplements. Common questions.

   • Side Effects

     Serious side effects. It's unusual to have serious side...

   • About Allopurinol

     During the first few months of treatment, as allopurinol...

   • Common Questions

     There are no foods or drink you need to avoid while taking...

3. www.nhs.uk › conditions › goutGout - NHS

   www.nhs.uk › conditions › gout

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   Gout is a type of arthritis that causes sudden, severe joint pain. Painkillers can help the pain and healthier lifestyle choices can prevent future attacks. Check if it's gout. The main symptoms of gout are: sudden severe pain in a joint – usually your big toe, but it can be in other joints in your feet, ankles, hands, wrists, elbows or knees

   • Video Duration: 3 min

   • Views: 24

4. www.bmj.com › content › 362Latest guidance on the management of gout | The BMJ

   www.bmj.com › content › 362

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   Jul 18, 2018 · What you need to know. An acute attack of gout is likely to require treatment with a NSAID (with gastroprotection for those at high risk of gastrointestinal complications) or colchicine. In general, urate lowering therapy (ULT) is targeted to patients with recurrent attacks, tophi, urate arthropathy, or renal damage and to symptomatic patients ...

   • Author: Drug and Therapeutics Bulletin

   • Publish Year: 2018

5. www.bmj.com › content › 378Gout: diagnosis and management—summary of NICE guidance

   www.bmj.com › content › 378

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   Aug 30, 2022 · Urate lowering therapy (ULT) should be given using a treat-to-target management strategy (aiming for a serum urate level <360 μmol/L (6 mg/dL)) to provide therapeutic cure. People without a major cardiovascular disease can be offered either allopurinol or febuxostat as first line treatment.

6. cks.nice.org.uk › topics › goutScenario: Acute gout | Management - CKS | NICE

   cks.nice.org.uk › topics › gout

   How to manage gout flares and the treatment options available. That gout is a lifelong condition that will benefit from long-term urate-lowering therapy (ULT) to eliminate urate crystals and prevent flares, shrink tophi and prevent long-term joint damage.

7. bnf.nice.org.uk › treatment-summaries › goutGout | Treatment summaries | BNF | NICE

   bnf.nice.org.uk › treatment-summaries › gout

   Treatment for an acute attack of gout should be started as soon as possible. Acute attacks are usually treated with either colchicine, high doses of an NSAID (excluding aspirin), or a short course of an oral corticosteroid. Consider prescribing a proton pump inhibitor for patients on NSAIDs.

8. cks.nice.org.uk › topics › goutAllopurinol | Prescribing information | Gout | CKS | NICE

   cks.nice.org.uk › topics › gout

   Prescribe a low starting dose of allopurinol 100 mg or less once daily (preferably taken after food) and adjust dose in 100 mg increments every 4 weeks according to plasma or serum urate level. 100-200 mg daily in mild conditions. 300-600 mg daily in moderately severe conditions. 700-900 mg daily in severe conditions.