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Jun 1, 2011 · As such, Mark was also the first to crystallize the role of cell cycle activation as a basic mechanism of cellular pathophysiology within the brain and the 2-hit hypothesis involving oxidative injury and cell cycle reentry as an upstream occurrence.
Dec 20, 2010 · The 45-year-old native of England was dubbed a renegade researcher for the way he challenged drug companies’ assumptions and other conventional wisdom on Alzheimer’s. Namely, he disagreed with ...
Drug discovery for neurodegenerative diseases: challenges and novel biochemical targets dedicated to the memory of Mark A. Smith for his inspiring contribution to Alzheimer's disease. J Alzheimers Dis. 2011;24 Suppl 2:1-2. doi: 10.3233/JAD-2011-110021.
Alzheimer disease (AD) research suffered a devastating loss with the death of Mark A. Smith on 19 December 2010. In addition to being the most prolific and fifth most cited AD author, Mark had a keen eye for innovation and quality of execution.
- Rudy J. Castellani, Robert B. Petersen, Hyoung gon Lee, Xiongwei Zhu, George Perry
- 2011
Mark Anthony Smith (August 15, 1965 – December 19, 2010) [1] was a professor of pathology at Case Western Reserve University in Cleveland, Ohio, where he also served as the Director of Basic Science Research at the University Memory and Aging Center.
Mark defined the first oxidative modifications found in AD and pioneered the foundation for cell cycle alteration and metabolic changes. He was also known for questioning the amyloid cascade hypothesis, providing evidence that amyloid-b (Ab) and tau are protective responses to brain injury.
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Mark Anthony Smith, PhD, was born in Leicester, UK, on August 15, 1965. The proud son of a coal miner, Mark grew up as a witness to hard work and sacrifice, and would carry himself throughout life with the appeal of a humble and virtuous upbringing.
