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Jul 1, 2008 · Ehrlich described the side-chain theory of antibody formation and the mechanisms of how antibodies neutralize toxins and induce bacterial lysis with the help of complement and thus is...
- Stefan H E Kaufmann
- 2008
The side-chain theory (German, Seitenkettentheorie) is a theory proposed by Paul Ehrlich (1854–1915) to explain the immune response in living cells. Ehrlich theorized from very early in his career that chemical structure could be used to explain why the immune response occurred in reaction to infection. He believed that toxins and antitoxins ...
In the early 1870s, Ehrlich's cousin Karl Weigert was the first person to stain bacteria with dyes and to introduce aniline pigments for histological studies and bacterial diagnostics.
Jul 1, 2013 · Side-Chain Theory, circa 1900. Paul Ehrlich came up with an explanation for cellular interactions based on receptors, earning a Nobel Prize and the title "Father of Modern Immunology"—only to have his theory forgotten.
- Edyta Zielinska
Sep 1, 2021 · In 1940, Linus Pauling proposed his template theory of antibody formation, one of many such theories that rejected Paul Ehrlich’s selective theory of preformed “receptors” (antibodies), assuming instead a direct molding of antibody shapes onto that of the antigen.
- Ute Deichmann
- 2021
Historical insight: Paul Ehrlich's dictum of horror autotoxicus and the changing orientation of the field inhibited acceptance of the reality of autoimmune disease.
Ehrlich’s selective theory for antibody production fell out of favor when Karl Landsteiner showed that antibodies could be raised against haptens produced by chemical synthesis.
