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Feb 12, 2024 · The best multivitamins and supplements for women at every stage of life, including the best vitamins for women over 30 and best women's multivitamin over 50.
- Nutrition Lab Director
- Results
- Relativity Strikes: High Placebo Response Complicates Findings
- A Safe Combination
- The Next Trial
- Wrap Up
The patients in the placebo arm of the Synergy trial averaged a 13% decline in their Checklist Individual Strength (CIS) scores. The patients taking the Synergy formula averaged 22% decline in their CIS scores. The difference between the two did not have statistical significance. In the FDA’s eyes the study would have been a failure. But what does ...
The large amount of patients in the placebo arm with a verypositive placebo response complicated the results. Dr. Kaiser said ten to fifteen of the patients had high enough placebo responses to, by the measures of the study, be considered cured. 1. 01-007 -27 point decline 2. 01-018 -39 point decline 3. 01-056 -60 point decline 4. 01-070 -62 point ...
Central nervous system stimulants like methylphenidate are powerful drugs that can have significant side effects. Dr. Kaiser said considerable concern was expressed regarding the effects of a stimulant on a possibly already stressed nervous system, but the drug combination proved safe. Methylphenidate appeared to be safe in the 2006 trial as well, ...
I asked Dr. Kaiser if he was satisfied with the response rate. He sounded like he was moderately satisfied but felt like they could do better, and listed four ways in which he expected that the next trial, if it is done, would have better results. 1. Employing a crossover trial in which the patient goes from placebo to drug or drug to placebo shoul...
All in all it was an odd result. A trial that succeeded on several levels but not on an important one. A trial that appeared, to be honest, to run into a bit of bad luck. Dr. Kaiser said he was encouraged by the safety and efficacy data but whether the Synergy team will be able to move on and possibly produce the first FDA approved treatment for ME...
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- KPAX Health
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