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This review summarizes the current knowledge on exosome contributions to AD as well as their use as disease biomarker resources or therapeutic targets. The most recent findings with respect to both protein and miRNA biomarker candidates for AD, herein described, highlight the state of the art in this field and encourage the use of exosomes ...
- Tânia Soares Martins, Dário Trindade, Margarida Vaz, Inês Campelo, Martim Almeida, Guilherme Trigo, ...
- 2021
The pathogenic contribution of exosomes in AD is not only restricted to the spread of amyloidogenic material and Tau, but it also extends to the spread of other molecular agents involved in key neurodegenerative AD processes, such as neuroinflammation (Domingues, da Cruz e Silva, & Henriques, 2017).
- Tânia Soares Martins, Dário Trindade, Margarida Vaz, Inês Campelo, Martim Almeida, Guilherme Trigo, ...
- 2021
Jul 3, 2020 · Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the world and exosomes appear to have a relevant role in disease pathogenesis. This review summarizes the current knowledge on exosome contributions to AD as well as their use as disease biomarker resources or therapeutic targets. The most recent findings with respect ...
Jan 1, 2017 · This review focuses on the role of cytokines and chemokines in AD-associated pathologies, and summarizes the potential anti-inflammatory therapeutic approaches aimed at preventing or slowing down disease progression. Keywords: Neuroinflammation, cytokines, chemokines, amyloid precursor protein, β-amyloid, TAU. 1.
Aβ is proteolytically produced from the Alzheimer’s amyloid precursor protein (APP). Major properties attributed to Aβ include neurotoxic effects that contribute to Alzheimer’s disease neurodegeneration.
Sep 19, 2020 · Abstract. Cancer cells take advantage of signaling cascades to meet their requirements for sustained growth and survival. Cell signaling is tightly controlled by reversible protein phosphorylation mechanisms, which require the counterbalanced action of protein kinases and protein phosphatases.
Jan 1, 2017 · This review focuses on some of the major protein kinases and protein phosphatases relevant to AD. Of particular relevance, posttranslational modifications dynamically regulate protein activity, subcellular localization, and stability.
