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Janet E. Mertz (born 1949) is an American biochemist, molecular biologist, and cancer researcher. [3] She is currently the Elizabeth McCoy Professor of Oncology in the McArdle Laboratory for Cancer Research at the University of Wisconsin–Madison. [4] Mertz is best known for disputing Lawrence Summers ' 2005 suggestion that women lack the ...
Articles 1–20. Professor of Oncology, University of Wisconsin, Madison - Cited by 8,189 - virology - hormone receptors - cancer.
Janet E. Mertz. EBV, a human herpesvirus, is latently present in most nasopharyngeal carcinomas, Burkitt lymphomas, and some gastric cancers. To develop a lytic-induction therapy for treating...
- Background
- Creating Recombinant DNA in Vitro
- Cloning in Bacteria
- Patenting and Start of Biotechnology Industry
- Development of Regulatory Guidelines
- Impacts of Recombinant DNA Technology
During the 1960s, enormous progress was made in understanding the structure of genes and the mechanisms of their replication, expression, and regulation in prokaryotes and the viruses that infect them. However, largely unknown at the end of that decade was whether these findings were applicable to eukaryotes, i.e., organisms with an authentic nucle...
Both SV40 and λdvgal 120 exist naturally as circular DNA molecules. Thus, as a first step, methods were needed to cleave each of them once to produce full-length linear molecules. This task was achieved in two ways. One procedure relied on the fact that circular DNAs can be cleaved to linear molecules by incubation with pancreatic DNase I in the pr...
Prior to 1972, Stanley Cohen14 had been studying the structure and replication of DNA plasmids such as pSC101 that bear antibiotic resistance genes in bacteria. Aware of the not-yet-published findings of Mertz and Davis (1972) and D. Berget al. (1974), Cohen realized that these techniques could be quite helpful for his research. In collaboration wi...
None of the members of the Berg, Kaiser, or Davis groups ever considered patenting the reagents or procedures that were used for recombining DNA in vitro. Neither had the scientists who discovered TdT, DNA polymerases, DNA ligases, exonucleases, and restriction enzymes ever sought patents for their efforts. Indeed, few, if any, of the discoveries, ...
Boyer's presentation of the Cohenet al. (1973) experiments, resulting in the creation of plasmids with novel combinations of antibiotic resistance genes, triggered concerns about the safety of such recombinants among the participants attending the June 1973 Gordon Conference on Nucleic Acids (Singer and Söll 1973). In response to those concerns, t...
The most far-reaching consequence of the emergence of the recombinant DNA technology has been the great strides made in understanding fundamental life processes and the ability to investigate problems that had previously been unapproachable. Emerging from myriad investigations has been the appreciation that nothing in the man-made world rivals the ...
- Paul Berg, Janet E Mertz
- 2010
Janet Mertz. Credentials: Professor Emeritus. Email: mertz@oncology.wisc.edu. Website: Janet Mertz's website. Phone: (608) 262-2383, (608) 262-2335. Address: 7507 WI Institutes for Medical Research
Sep 9, 2013 · Berg and his graduate student Janet Mertz planned to introduce these SV40-λdvgal hybrid DNA molecules into mammalian cells to determine whether the bacterial gene would function there (54, 67), and he and Mertz have written that they also wished to propagate the SV40-λdvgal hybrid DNA molecules in E. coli (67,68).
Janet E. Mertz, PhD. Position title: PROFESSOR. Email: mertz@oncology.wisc.edu. Phone: (608) 262-2383, (608) 262-2335. Address: 7507 WIMR II 1111 Highland Ave Madison, WI 53705
