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  1. In vivo hMSCs are sources of trophic factors modulating the immune system and inducing intrinsic stem cells to repair damaged tissues. Currently, there are multiple clinical trials (CT) using hMSCs for therapeutic purposes in a large number of clinical settings.

  2. Aug 25, 2022 · Stem cells are types of cells that have unique ability to self-renew and to differentiate into more than one cell lineage. They are considered building blocks of tissues and organs. Over recent decades, they have been studied and utilized for repair and regenerative medicine.

  3. Oct 10, 2021 · As therapeutics, mesenchymal stem cells or even just their secreted products may be used to regenerate tissue lost through injury or disease and suppress damaging immune reactions. However, these cells lack unique markers and are hard to identify and isolate as pure cell populations.

    • David Kuntin, Paul Genever
    • 2021/10/10
    • 10.1042/ETLS20200303
  4. Jan 15, 2014 · Haematopoietic stem cell (HSC) niches are present in diverse tissues throughout development, beginning in the aorta–gonad–mesonephros (AGM) region and the yolk sac, followed by the placenta,...

    • Sean J. Morrison, David T. Scadden
    • 2014
  5. Jan 16, 2014 · Abstract. Niches are local tissue microenvironments that maintain and regulate stem cells. Haematopoiesis provides a model for understanding mammalian stem cells and their niches, but the haematopoietic stem cell (HSC) niche remains incompletely defined and beset by competing models.

    • Sean J. Morrison, David T. Scadden
    • 2014
  6. We begin by discussing experimental advances in the generation and differentiation of pluripotent stem cells (PSCs), next moving to the maintenance of stem cells in different culture types, and finishing with a discussion of three-dimensional (3D) cell technology and future stem cell applications.

  7. Oct 29, 2021 · As therapeutics, mesenchymal stem cells or even just their secreted products may be used to regenerate tissue lost through injury or disease and suppress damaging immune reactions. However, these cells lack unique markers and are hard to identify and isolate as pure cell populations.

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