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1. www.nature.com › articles › s41467/024/50021-9Hematopoietic stem and progenitor cell membrane-coated ...

   www.nature.com › articles › s41467/024/50021-9

   1 day ago · Further, we examined the proportions of hematopoietic stem cells, progenitor cells, and lineage cells in the bone marrow and found no significant difference between the HSPC-Lipo treatment and ...

2. pubmed.ncbi.nlm.nih.gov › 38749423An age-progressive platelet differentiation path from ...

   pubmed.ncbi.nlm.nih.gov › 38749423

   Jun 6, 2024 · Platelet dysregulation is drastically increased with advanced age and contributes to making cardiovascular disorders the leading cause of death of elderly humans. Here, we reveal a direct differentiation pathway from hematopoietic stem cells into platelets that is progressively propagated upon aging …

3. www.nature.com › articles › s41586/021/03609-wBase editing of haematopoietic stem cells rescues sickle cell ...

   www.nature.com › articles › s41586/021/03609-w

   Jun 2, 2021 · Ex vivo delivery of mRNA encoding the base editor with a targeting guide RNA into haematopoietic stem and progenitor cells (HSPCs) from patients with SCD resulted in 80% conversion of HBBS to...

   • Author: Gregory A. Newby, Gregory A. Newby, Gregory A. Newby, Jonathan S. Yen, Kaitly J. Woodard, Thiyagaraj...

   • Publish Year: 2021

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5. www.ncbi.nlm.nih.gov › pmc › articlesHematopoietic Stem Cell Gene Therapy –Progress and Lessons ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 2, 2017 · Hematopoietic stem cells (HSCs) isolated from bone marrow can be modified ex vivo and transferred back to the recipient to produce functional, terminally-differentiated cells. Specific cellular targets and the relevant diseases and genes for gene therapy include the following: HSCs: Fanconi Anemia (FANC A–F).

   • Author: Richard A. Morgan, David Gray, Anastasia Lomova, Donald B. Kohn
   • DOI: 10.1016/j.stem.2017.10.010

   • Publish Year: 2017
   • Published: 2017/11/11

6. www.ncbi.nlm.nih.gov › pmc › articlesBase editing of hematopoietic stem cells rescues sickle cell ...

   www.ncbi.nlm.nih.gov › pmc › articles

   After sixteen weeks, Makassar β-globin represented 79% of β-globin protein in blood and hypoxia-induced sickling was reduced 3-fold. Mice receiving base-edited HSPCs showed rescue of hematologic parameters to near-normal levels and reduced splenic pathology compared to unedited controls.

   • Author: Gregory A. Newby, Gregory A. Newby, Gregory A. Newby, Jonathan S. Yen, Kaitly J. Woodard, Thiyagaraj...
   • DOI: 10.1038/s41586-021-03609-w

   • Publish Year: 2021
   • Published: 2021/07

7. pubmed.ncbi.nlm.nih.gov › 16877336Hematopoietic stem cells: the paradigmatic tissue-specific ...

   pubmed.ncbi.nlm.nih.gov › 16877336

   Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls.

8. People also ask

   Can hematopoietic stem cells be edited?

   • Secondary transplantation of edited bone marrow confirmed durable editing of long-term hematopoietic stem cells and revealed that ≥20% HBBS -to- HBBG editing is sufficient for phenotypic rescue. Base editing of human HSPCs avoided p53 activation and larger deletions observed following Cas9 nuclease treatment.

   Base editing of hematopoietic stem cells rescues sickle cell disease in

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8266759/

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   Who are the authors of gene editing in human stem cells?

   • Lombardo A, Pietro Genovese Beausejour CM, Colleoni S, Lee Y-L, Kim KA, Ando D, Urnov FD, Galli C, Gregory PD, Holmes MC, Naldini L. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery.

   Hematopoietic Stem Cell Gene Therapy –Progress and Lessons Learned

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6039108/

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   Are autologous hematopoietic stem cells safe?

   • The use of allogeneic hematopoietic stem cells (HSCs) to treat genetic blood cell diseases has become a clinical standard but is limited by availability of suitable matched donors and potential immunologic complications. Gene therapy using autologous HSCs should avoid these limitations and thus may be safer.

   Hematopoietic Stem Cell Gene Therapy –Progress and Lessons Learned

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6039108/

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   What are hematopoietic stem cells?

   • Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls.

   Hematopoietic stem cells: the paradigmatic tissue-specific stem cell

   pubmed.ncbi.nlm.nih.gov/16877336/

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9. www.cell.com › cell › fulltextEpigenetic memory of coronavirus infection in ... - Cell Press

   www.cell.com › cell › fulltext

   Aug 18, 2023 · Severe COVID-19 can reprogram hematopoiesis and establish epigenetic memory in hematopoietic stem and progenitor cells (HSPC) and progeny myeloid cells for up to 1 year. These durable alterations, which could affect post-infection immune responses and equilibrium, are controlled in part by the activity of IL-6 during acute disease.