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Feb 16, 2023 · Cardiac fibrosis is an aberrant thickening of the heart valves caused by unsuitable fibroblast proliferation, but it is more frequently used to describe the excessive deposition of ECM in the cardiac muscle, as described in Figure 12 . Numerous cell types, including cardiomyocytes and fibroblasts, can be found in the myocardium.
- 10.3390/ijms24044004
- 2023/02
- Int J Mol Sci. 2023 Feb; 24(4): 4004.
Mar 6, 2018 · In this review, we discuss the current knowledge with respect to the mechanisms that allow pre-mRNA transcripts to undergo muscle-specific alternative splicing while identifying some of the key trans -acting splicing factors essential to the process.
- Kiran Nakka, Claudia Ghigna, Davide Gabellini, F. Jeffrey Dilworth, F. Jeffrey Dilworth
- 2018
Mar 1, 2024 · Reduction of the aberrant Junb expression in MuSCs or reduction of Tgfb1 levels in denervated muscles might be an additional starting point for improving MuSC functionality and thereby whole ...
May 4, 2014 · Alternative and faster ways to trigger fibrosis in the limb muscle of mdx mice are based on surgical and chemical damage, such as laceration or denervation. Laceration consists in a deep cut across the muscle [ 87 ] which causes a delay in the healing process, while the denervation model involves severing the sciatic nerve, thus causing atrophy ...
- Yacine Kharraz, Joana Guerra, Patrizia Pessina, Antonio L. Serrano, Pura Muñoz-Cánoves
- 10.1155/2014/965631
- 2014
- Biomed Res Int. 2014; 2014: 965631.
May 4, 2011 · The net consequence of these alterations firstly involves progressive atrophy and loss of individual muscle fibers, associated with concomitant loss of motor units . In addition, there is infiltration of fat and other non-contractile material, which causes a reduction in muscle 'quality' .
Jul 29, 2013 · Aberrant splicing saps the strength of 'slow' muscle fibers. by Baylor College of Medicine. When you sprint, the "fast" muscle fibers give you that winning kick. In a marathon or just...
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May 4, 2011 · This article reviews the emerging findings of the mechanisms that underlie normal versus aberrant muscle-tissue repair. The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals.
