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May 4, 2011 · Replacement of damaged muscle fibers is dependent on satellite cells, resident stem cells that are normally quiescent, and are located under the basal lamina of muscle fibers. Tissue damage leads to their activation, proliferation, differentiation and fusion to form new myofibers.
Mar 6, 2018 · In this review, we discuss the current knowledge with respect to the mechanisms that allow pre-mRNA transcripts to undergo muscle-specific alternative splicing while identifying some of the key trans-acting splicing factors essential to the process.
- Kiran Nakka, Claudia Ghigna, Davide Gabellini, F. Jeffrey Dilworth, F. Jeffrey Dilworth
- 2018
Feb 19, 2018 · Skeletal muscle formation (myogenesis) is a multi-step process that is tightly regulated by a complex network of muscle specific and ubiquitous transcription factors (TFs).
- Carol Imbriano, Susanna Molinari
- 10.3390/genes9020107
- 2018
- Genes (Basel). 2018 Feb; 9(2): 107.
Jan 14, 2020 · We investigated the gene expression patterns of skeletal muscle cells using RNA-seq of subtype-pooled single human muscle fibers and single cell RNA-seq of mononuclear cells from human vastus...
- Aliza B. Rubenstein, Gregory R. Smith, Ulrika Raue, Gwénaëlle Begue, Kiril Minchev, Frederique Ruf-Z...
- 2020
Jul 29, 2013 · Researchers have shown how an aberrant alternative splicing program changes the form of an enzyme involved in the fundamental metabolism of these muscle cells, leaving them unable to sustain...
May 4, 2011 · Within the muscle, the presence of inflammatory infiltrates composed largely of macrophages, T cells and dendritic cells correlates with immune-mediated loss of muscle fibers and an inability to resolve the regeneration process effectively.
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Jan 1, 2011 · Aberrant or dysregulated ECM accumulation during repair is thus the classical definition of fibrosis. Finally, in addition to ECM remodeling, angiogenesis facilitates development of a new vascular network at the site of injury while newly formed muscle fibers undergo growth and maturation.
