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Despite the wealth of pre-clinical data favoring an aberrant learning and memory conception of addiction, there is a lack of clinical research exploring exactly how learning accrues to drug predicting stimuli in human subjects.
- Mary M. Torregrossa, Philip R. Corlett, Jane R. Taylor
- 2011
Sep 21, 2022 · In this framework, repeated exposure to addictive substances alters dopamine signaling in mesolimbic and mesocortical circuits, which results in aberrant learning and an overvaluation of the...
Another theory described by Robinson and Berridge (2003) involves aberrant learning suggesting that drugs create a strong connection to natural reward centers based on learning through classical conditioning. Pinel (2009) refers to this theory as the Positive-incentive theories of drug addiction.
Nov 26, 2021 · With respect to neuroadaptations, the crucial questions are how excessive the hyper-reactivity to drug cues and hypo-reactivity to non-drug alternative reward cues is, and whether there is reason to view this excess as crossing a threshold from atypical function into dysfunction.
Nov 1, 2011 · In this review, we will focus on how drugs of abuse alter normal learning and memory and discuss how specific vulnerability factors influence the ability of abused drugs to affect learning and memory systems.
- Mary M. Torregrossa, Philip R. Corlett, Jane R. Taylor
- 2011
This conceptualisation of addiction as the aberrant engagement of normal learning processes makes psychological and neurobiological studies of learning and motivation relevant to addiction research.
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Aug 29, 2023 · This suggests that for HD individuals, aversive reinforcers may yield better learning-based shifts in attention, compared with positive reinforcers, reflecting a specific aberration in reward-related selection history in depression.
