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Sep 11, 2013 · It will be possible to understand how aberrant alternative splicing can contribute to carcinogenesis and to the progression of disease. This is illustrated by a recent study in which normal epithelial cells were stressed with nicotine.
- Michael Ladomery
- 10.1155/2013/463786
- 2013
- Int J Cell Biol. 2013; 2013: 463786.
Apr 16, 2021 · Many studies have reported that alternative splicing and aberrant splicing are related to splicing variants related to signaling pathways, leading to cell proliferation and cell death in cancer cells (Table 2). Splicing variants of RAF downstream of KRAS have been reported.
- Koji Kitamura, Keisuke Nimura
- 10.3390/cells10040923
- 2021
- Cells. 2021 Apr; 10(4): 923.
Sep 21, 2023 · The results showed that 237 AS events were found to be significantly correlated with stromal content, while 100 AS events were found to be significantly correlated with immunoinfiltration (adjusted P-value ≤ 0.05 and |Spearman correlation coefficient r|≥ 0.5), suggesting the potential role of alternative splicing in CRC microenvironment ...
Sep 21, 2020 · Here, we describe the first crystal structures of wild-type and pathogenic mutant U2AF1 complexed with target RNA, revealing the mechanism of 3´ splice site selection, and how aberrant splicing...
- Hisashi Yoshida, Sam-Yong Park, Gyosuke Sakashita, Yuko Nariai, Kanako Kuwasako, Yutaka Muto, Takesh...
- 2020
Apr 3, 2023 · Splicing factors systemically activate and regulate the alternative splicing of target gene pre-mRNA. A subset of genetic mutations induces aberrant alternative splicing.
Jan 4, 2021 · Long-read sequencing of full-length cDNAs enables the detection of structures of aberrant splicing isoforms in cancer cells. These isoforms are occasionally translated, presented by HLA molecules, and recognized as neoantigens.
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Are alternative splicing variants related to a signaling pathway?
Does aberrant splicing regulation affect signal transduction pathways?
How is alternative splicing controlled?
Are accumulated aberrant splicing peptides neoantigens?
Oct 29, 2023 · Knockdown of SRSF1 was found to increase KLF6 SV1 mRNA expression in human HCC cell lines. SRSF1 is involved in regulating KLF6 alternative splicing. Activated AKT1 can phosphorylate SRSF1, thereby promoting the generation of KLF6 SV1 and subsequently enhancing cellular proliferation.