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1. www.ncbi.nlm.nih.gov › pmc › articlesAberrant Alternative Splicing Is Another Hallmark of Cancer

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 11, 2013 · It will be possible to understand how aberrant alternative splicing can contribute to carcinogenesis and to the progression of disease. This is illustrated by a recent study in which normal epithelial cells were stressed with nicotine.

   • Author: Michael Ladomery
   • DOI: 10.1155/2013/463786

   • Publish Year: 2013
   • Publication: Int J Cell Biol. 2013; 2013: 463786.

2. www.ncbi.nlm.nih.gov › pmc › articlesRegulation of RNA Splicing: Aberrant Splicing Regulation and ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Apr 16, 2021 · Many studies have reported that alternative splicing and aberrant splicing are related to splicing variants related to signaling pathways, leading to cell proliferation and cell death in cancer cells (Table 2). Splicing variants of RAF downstream of KRAS have been reported.

   • Author: Koji Kitamura, Keisuke Nimura
   • DOI: 10.3390/cells10040923

   • Publish Year: 2021
   • Publication: Cells. 2021 Apr; 10(4): 923.

3. genomemedicine.biomedcentral.com › articles › 10Long-read sequencing reveals the landscape of aberrant ...

   genomemedicine.biomedcentral.com › articles › 10

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   Sep 21, 2023 · The results showed that 237 AS events were found to be significantly correlated with stromal content, while 100 AS events were found to be significantly correlated with immunoinfiltration (adjusted P-value ≤ 0.05 and |Spearman correlation coefficient r|≥ 0.5), suggesting the potential role of alternative splicing in CRC microenvironment ...

4. www.nature.com › articles › s41467/020/18559-6Elucidation of the aberrant 3′ splice site selection by ...

   www.nature.com › articles › s41467/020/18559-6

   Sep 21, 2020 · Here, we describe the first crystal structures of wild-type and pathogenic mutant U2AF1 complexed with target RNA, revealing the mechanism of 3´ splice site selection, and how aberrant splicing...

   • Author: Hisashi Yoshida, Sam-Yong Park, Gyosuke Sakashita, Yuko Nariai, Kanako Kuwasako, Yutaka Muto, Takesh...

   • Publish Year: 2020

5. www.nature.com › articles › s12276/023/00981-7The implications of alternative pre-mRNA splicing in cell ...

   www.nature.com › articles › s12276/023/00981-7

   Apr 3, 2023 · Splicing factors systemically activate and regulate the alternative splicing of target gene pre-mRNA. A subset of genetic mutations induces aberrant alternative splicing.

6. genomebiology.biomedcentral.com › articles › 10Aberrant splicing isoforms detected by full-length ...

   genomebiology.biomedcentral.com › articles › 10

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   Jan 4, 2021 · Long-read sequencing of full-length cDNAs enables the detection of structures of aberrant splicing isoforms in cancer cells. These isoforms are occasionally translated, presented by HLA molecules, and recognized as neoantigens.

7. People also ask

   Are alternative splicing variants related to a signaling pathway?

   • Many studies have reported that alternative splicing and aberrant splicing are related to splicing variants related to signaling pathways, leading to cell proliferation and cell death in cancer cells ( Table 2 ). Splicing variants of RAF downstream of KRAS have been reported.

   Regulation of RNA Splicing: Aberrant Splicing Regulation and

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8073995/

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   Does aberrant splicing regulation affect signal transduction pathways?

   • However, aberrant splicing regulation via genetic mutation or abnormal expression of splicing factors negatively affects signal transduction pathways and is associated with the onset and progression of various diseases, including cancer.

   The implications of alternative pre-mRNA splicing in cell signal

   www.nature.com/articles/s12276-023-00981-7

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   How is alternative splicing controlled?

   • The process of alternative splicing is under strict control by a trans-acting splicing factor that attaches to a splicing regulatory motif for HCC splicing (Wang et al. 2019a; Marasco and Kornblihtt 2022 ). SR proteins and hnRNPs are two significant families of splicing regulators that play vital roles in the splicing process.

   Decoding the role of aberrant RNA alternative splicing in ... - Springer

   link.springer.com/article/10.1007/s00432-023-05474-8

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   Are accumulated aberrant splicing peptides neoantigens?

   • Accumulated aberrant splicing isoforms in tumors have been reported as possible sources of neoantigens [ 29, 30, 31 ]. To investigate whether the detected isoforms can be represented as neoantigens, we attempted to evaluate the potential antigenicity of the aberrant peptides encoded by these aberrant splicing isoforms.

   Aberrant splicing isoforms detected by full-length transcriptome

   genomebiology.biomedcentral.com/articles/10.1186/s13059-020-02240-8

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8. link.springer.com › article › 10Decoding the role of aberrant RNA alternative splicing in ...

   link.springer.com › article › 10

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   Oct 29, 2023 · Knockdown of SRSF1 was found to increase KLF6 SV1 mRNA expression in human HCC cell lines. SRSF1 is involved in regulating KLF6 alternative splicing. Activated AKT1 can phosphorylate SRSF1, thereby promoting the generation of KLF6 SV1 and subsequently enhancing cellular proliferation.