ELISA Based Kits Development of ELISA for Specific Detection of Disease-related Proteins. Fast, Automated, Economical, Sensitive, Small Quantities of Samples/Reagents Consuming.
Search results
- The discovery and development of clinically useful antibiotic classes, such as the aminoglycosides, macrolides and tetracyclines, have clearly demonstrated that bacterial protein synthesis is a suitable target for drug intervention.
People also ask
How do antibiotics affect protein synthesis?
Where does protein synthesis occur?
Do antimicrobials bind DNA replication proteins?
Are replication proteins a target for antimicrobial compounds?
Do macrolide antibiotics synthesis a small subset of proteins?
What are the four steps of protein synthesis?
Objective: to understand which translation initiation steps could represent a novel or underexploited target for the discovery of new and specific antibacterial drugs. Methods: Brief descriptions of the properties and mechanism of action of the major antibiotics that have a documented direct inhibitory effect on bacterial translation initiation ...
- Bacterial Protein Synthesis as a Target for Antibiotic ...
Protein synthesis occurs on macromolecular machines, called...
- Bacterial Protein Synthesis as a Target for Antibiotic ...
Many of the antibiotics currently in use target the bacterial ribosome and usually hamper protein synthesis by binding to ribosomal functional centers, such as the decoding center, the peptidyl transferase center, and the peptide exit tunnel.
Jan 10, 2017 · Antimicrobials targeting DNA replication proteins that bind their targets at the active site, such as the aminocoumarins, have a relatively low risk of resistance, since mutations that affect drug–protein binding tend to lead to a non-functional protein.
- Erika van Eijk, Bert Wittekoek, Ed J. Kuijper, Wiep Klaas Smits
- 2017
Dec 16, 2013 · Most antibiotics that target the 50S subunit inhibit protein synthesis by either perturbing the binding of aminoacylated-tRNAs at the A- or P-sites or preventing the channelling of the...
- Daniel N. Wilson
- Wilson@genzentrum.lmu.de
- 2014
Protein synthesis can be divided into four main steps: initiation, elongation, termination, and ribosome recycling, each of which is targeted by a plethora of different antibiotics (Fig. 2) (Wilson 2009, 2014).
Protein syn-thesis can be divided into four main steps: ini-tiation, elongation, termination, and ribosome recycling, each of which is targeted by a plethora of different antibiotics (Fig. 2) (Wilson 2009, 2014).
Sep 1, 2016 · Protein synthesis occurs on macromolecular machines, called ribosomes. Bacterial ribosomes and the translational machinery represent one of the major targets for antibiotics in the cell. Therefore, structural and biochemical investigations into ribosome-targeting antibiotics provide not only insight ….
