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- The discovery and development of clinically useful antibiotic classes, such as the aminoglycosides, macrolides and tetracyclines, have clearly demonstrated that bacterial protein synthesis is a suitable target for drug intervention.
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Objective: to understand which translation initiation steps could represent a novel or underexploited target for the discovery of new and specific antibacterial drugs. Methods: Brief descriptions of the properties and mechanism of action of the major antibiotics that have a documented direct inhibitory effect on bacterial translation initiation ...
- Bacterial Protein Synthesis as a Target for Antibiotic ...
Protein synthesis occurs on macromolecular machines, called...
- Bacterial Protein Synthesis as a Target for Antibiotic ...
Protein synthesis can be divided into four main steps: initiation, elongation, termination, and ribosome recycling, each of which is targeted by a plethora of different antibiotics (Fig. 2) (Wilson 2009, 2014).
Protein synthesis is initiated on the 30S subunit with the help of initiation factors which recruit the initiator formyl-methionine transfer RNA (fMet-tRNA i fMet) in the ribosomal peptidyl (P) site [reviewed in ]. The 50S subunit associates with the 30S, forming the 70S initiation complex that is primed for the elongation phase of protein synthesis.
Protein syn-thesis can be divided into four main steps: ini-tiation, elongation, termination, and ribosome recycling, each of which is targeted by a plethora of different antibiotics (Fig. 2) (Wilson 2009, 2014).
Jul 22, 2021 · The ribosome and protein synthesis represent one of the major targets in the bacterial cell for clinically-relevant antibiotics 1,2.
- Bertrand Beckert, Elodie C. Leroy, Shanmugapriya Sothiselvam, Lars V. Bock, Maxim S. Svetlov, Michae...
- 2021
Sep 1, 2016 · Protein synthesis occurs on macromolecular machines, called ribosomes. Bacterial ribosomes and the translational machinery represent one of the major targets for antibiotics in the cell. Therefore, structural and biochemical investigations into ribosome-targeting antibiotics provide not only insight ….
Apr 15, 2008 · This review summarizes the recent advances in the understanding of protein synthesis, particularly with respect to X-ray and cryoelectron microscopy structures of ribosome complexes, and highlights the different steps of translation that are targeted by the diverse array of known antibiotics.
