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Jun 7, 2021 · The Hippo pathway is pervasively activated and has been well recognized to play critical roles in human cancer. The deregulation of Hippo signaling involved in cancer development, progression, and resistance to cancer treatment have been confirmed in several human cancers. Its biological significance and deregulation in cancer have drawn ...
- Qiuping Liu, Xiaomeng Liu, Guanbin Song
- 10.3390/cells10061416
- 2021
- Cells. 2021 Jun; 10(6): 1416.
Dec 10, 2021 · In view of the prevalence of the dysregulated Hippo pathway in cancer, compounds have been developed to decrease YAP expression (e.g., CA3), block the interaction between YAP/TAZ and TEAD (e.g., verteporfin, bis-aryl hydrazine scaffold, and VGLL4 peptide), or target the palmitoylation pocket of TEAD (e.g., flufenamic acid) [63,64]. The effectiveness of these inhibitors in restraining tumor ...
- Yi Xiao, Jixin Dong
- Cancers (Basel). 2021 Dec; 13(24): 6214.
- 10.3390/cancers13246214
- 2021/12
Jan 16, 2021 · In line with these observations, the synergistic combination of verteporfin and AG1478, an inhibitor of EGFR, was observed to reverse 5-FU resistance in cultured cells and mice. Other colon cancer research has shown the c-Yes/YAP axis drives 5-FU resistance through the combined acquisition of cell quiescence and stemness . Collectively, these ...
- Renya Zeng, Jixin Dong
- 10.3390/cancers13020318
- 2021
- Cancers (Basel). 2021 Jan; 13(2): 318.
Jul 26, 2022 · A study links eating fish often with higher risk of melanoma. Melanoma, the most serious type of skin cancer, is responsible for more than 7,500 deaths in the U.S. each year. And cases are on the rise. In the new study, researchers found a higher risk of melanoma among people who ate the most fish. This study is among the largest and most well ...
Jun 1, 2021 · The role of the Hippo pathway in regulating cancer stem cell proliferation is also shown by the knockout of upstream hippo components such as Merlin, or double knockout of Mst1 and Mst2, or knockout of Sav1 in mice liver which results in accumulation of oval cells and adult liver stem cells that subsequently induce tumor formation [66, 67, 70]. These pieces of evidence support the role of the ...
- Suman Mohajan, Praveen Kumar Jaiswal, Mousa Vatanmakarian, Hassan Yousefi, Saikolappan Sankaralingam...
- 2021
The Hippo pathway regulates myriad biological processes in diverse species and is a key cancer signaling network in humans. Although Hippo has been linked to multiple aspects of cancer, its role in this disease is incompletely understood. Large-scale pan-cancer analyses of core Hippo pathway genes reveal that the pathway is mutated at a high ...
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What role does Hippo play in human cancer?
How is Hippo pathway altered in human cancer?
Does Hippo pathway deregulation cause cancer?
How many people are killed by Hippos in Africa?
Jan 29, 2021 · By some estimates, about 40 people—mostly fishermen—were attacked by hippos on Lake Naivasha in 2020, and as many as 14 of them died. Every year across Africa, hippos kill an estimated 500 ...
