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  2. Oct 27, 2017 · Fear reaction starts in the brain and spreads through the body to make adjustments for the best defense, or flight reaction. The fear response starts in a region of the brain called the...

    • Two Pathways of Fear
    • Fear Versus Worry
    • Other Brain Areas Involved in Fear, Stress, and Anxiety
    • Summary

    Neuroscientist Joseph LeDoux’s research with rodents helped us understand the brain circuitry of fear. LeDoux suggested there was both a “low road” and a “high road” of fear. The “low road” involved activation of the amygdala, a structure in the midbrain that served to detect a threat to our survival and set into motion a biobehavioral response tha...

    More recently, brain researchers have found that fear and anxiety/worry may have distinct neural circuitry. Fear can be thought of as the response to an immediate and present danger, while anxiety/worry involves a response to uncertain and possibly negative future events. While fear-arousal comes from the amygdala, it seems that anxiety is associat...

    The medial prefrontal cortex The medial prefrontal cortex (MPFC) is a part of the prefrontal cortex involved in processing information about ourselves and other people. Studies of PTSD patients find less MPFC activation overall in this group compared to healthy controls. However, people with PTSD have more MPFC activation than controls in response ...

    New research using fMRI imaging to scan the brain in real-time has shown that anxiety and stress disorders seem to be “whole brain” conditions, rather than being limited to one or two brain areas. Brain areas involved in generating fear and threat responses are the amygdala, the insula and the dorsal anterior cingulate. Those regions involved in mo...

  3. Oct 27, 2020 · Fear sets in, and your brain gets to work. Your amygdala, an area of your brain that helps you take in and respond to emotions, immediately presses the panic button. Because fear isn't just any emotion. It's a powerful, primitive one that your brain and body rely on to maintain your safety.

  4. Sep 8, 2023 · Fear—and other mental states—are cognitive responses to the stimuli detected by the amygdala. The interactions of the various systems involved, he argues, create a working memory...

  5. Apr 29, 2020 · Perceived threats trigger our fight or flight response. Those threat signals that move in the brain from the amygdala to the hypothalamus to the pituitary gland, which secretes the hormone ACTH, and the adrenal glands, which release adrenalin.

  6. Jun 29, 2018 · Normally, the brain manages our fear and anxiety without allowing them to interfere with our daily functioning. If there’s a nearby threat, different areas of the brain help us make sense of the threat by amplifying or quelling our anxiety and fear.

  7. Jan 1, 2013 · Studies in rodents show that there are highly specific brain circuits for fear, whereas findings from human neuroimaging seem to make the opposite claim. Here I review the field and urge three approaches that could reconcile the debates.

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