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- A protein synthesis inhibitor is a substance that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins. It usually refers to substances, such as antimicrobial drugs, that act at the ribosome level.
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Aug 3, 2023 · Protein synthesis inhibitors usually act at the ribosomal level in the translation process of protein synthesis that includes initiation, elongation, and termination. In both prokaryotes and eukaryotes, ribosomes are the main site for protein synthesis.
In general, protein synthesis inhibitors work at different stages of bacterial mRNA translation into proteins, like initiation, elongation (including aminoacyl tRNA entry, proofreading, peptidyl transfer, and bacterial translocation) and termination: Earlier stages.
Protein synthesis inhibitors represent another major group of clinically useful antibacterials, such as erythromycin, tetracycline, chloramphenicol, and aminoglycosides. They selectively interact with the 70S bacterial ribosome and spare the 80S eukaryotic ribosome particle.
Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor, antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small-molecule drugs is known that specifically inhibit protein synthesis in eukaryotic cells.
- S. E. Dmitriev, S. E. Dmitriev, D. O. Vladimirov, K. A. Lashkevich
- 2020
Because antibiotics inhibit protein synthesis by targeting specific functional centers of the ribosome, we discuss inhibitors based on their binding sites in the ribosome. We describe their modes of action, as well as prominent examples of the resistance mechanisms that have developed among pathogens.
Aug 26, 2023 · Cytotoxicity by immunotoxins—approved inhibitors of protein synthesis—was synergistically enhanced in combination with UPR-inducers in seven distinct hematologic and three solid tumor...
