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      • Few among the millions of fungal species fulfill four basic conditions necessary to infect humans: high temperature tolerance, ability to invade the human host, lysis and absorption of human tissue, and resistance to the human immune system.
      pubmed.ncbi.nlm.nih.gov/25367975/
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  2. Few among the millions of fungal species fulfill four basic conditions necessary to infect humans: high temperature tolerance, ability to invade the human host, lysis and absorption of human tissue, and resistance to the human immune system.

  3. Infection of humans can be achieved only by fungi that secrete hydrolases suitable to digest human tissue, which include primary mammalian pathogens such as Histoplasma capsulatum (67, 68) and incidental, opportunistic pathogens such as Fusarium spp. (69) or Aspergillus fumigatus (70).

  4. Jun 25, 2024 · In this Review, we provide a broad and comprehensive overview of the pathobiology of human fungal infections, focusing specifically on pathogens that can cause invasive life-threatening...

    • Gordon D. Brown
  5. Of all the fungi that have been implicated in human disease, only the six agents that cause the systemic mycoses have the innate ability to cause infection and disease in humans and other animals. The primary site of infection is the respiratory tract.

    • George S. Kobayashi
    • 1996
    • 1996
  6. Apr 25, 2019 · Recent studies estimate that fungal infections, especially those caused by Candida, Cryptococcus and Aspergillus species, kill more than one million people annually.

    • Guilhem Janbon, Jessica Quintin, Fanny Lanternier, Christophe d'Enfert
    • 2019
  7. May 4, 2022 · Support for this hypothesis comes from clinical case reports of invasive infections by diverse well-known species of fungi that are thought to be harmless to humans.

  8. Fungi must meet four criteria to infect humans: growth at human body temperatures, circumvention or penetration of surface barriers, lysis and absorption of tissue, and resistance to immune defenses, including elevated body temperatures.

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