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- In response to stress conditions or nutrient depletion, bacterial cells reduce ribosome biogenesis, modify ribosomes and components of the translational machinery, and regulate translation initiation and elongation for adapting protein synthesis to changing conditions (Fig. 1).
www.ncbi.nlm.nih.gov/pmc/articles/PMC10502375/Coping with stress: How bacteria fine-tune protein synthesis ...
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Aug 14, 2023 · Still, for rapid inhibition of protein synthesis, bacteria need to execute additional strategies. One strategy is the direct inhibition of initiation and elongation factors during stress conditions, and the second is the stress-induced modification of the translational machinery.
Feb 14, 2024 · A study identifies a new bacterial ribosome hibernation factor, Balon, and describes its association with EF-Tu and its initiation of mRNA-independent hibernation during protein synthesis.
Sep 1, 2023 · In response to stress conditions or nutrient depletion, bacterial cells reduce ribosome biogenesis, modify ribosomes and components of the translational machinery, and regulate translation initiation and elongation for adapting protein synthesis to changing conditions (Fig. 1).
Jan 8, 2021 · In fact, it has been shown that synthesis of stress-related proteins can be induced by the administration of antibiotics which target the ribosome such as chloramphenicol (cold-shock proteins) and kanamycin (heat-shock proteins) (Van Bogelen and Neidhardt, 1990). Aside from this, the ribosomes and the translational apparatus play a fundamental ...
- He Cheng-Guang, Claudio Orlando Gualerzi
- 10.3389/fmicb.2020.619038
- 2021
- Front Microbiol. 2020; 11: 619038.
Jan 1, 2024 · Antibiotics inhibit bacterial growth by affecting fundamental processes in cells, such as cell membrane biogenesis, DNA replication, RNA transcription and protein synthesis [111]. Importantly, protein biosynthesis is a major target and a majority of translation inhibitors directly target the ribosome [112].
Aug 1, 2023 · Finally, we describe mechanisms that allow bacteria to maintain the transport of stress-responsive proteins under conditions when the canonical protein targeting pathways are impaired.
Jan 12, 2021 · Bacteria power their energy metabolism using membrane-bound respiratory enzymes that capture chemical energy and transduce it by pumping protons or Na + ions across their cell membranes.
