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Dec 24, 2022 · Protein synthesis inhibitors work at different stages of prokaryotic mRNA translation into proteins like initiation, elongation (including aminoacyl tRNA entry, proofreading, peptidyl transfer, and ribosomal translocation), and termination.
Jul 22, 2021 · Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit protein synthesis by binding within the exit tunnel of the bacterial ribosome.
- Bertrand Beckert, Elodie C. Leroy, Shanmugapriya Sothiselvam, Lars V. Bock, Maxim S. Svetlov, Michae...
- 2021
Sep 13, 2021 · Most macrolides interact with 23S rRNA within the 50S ribosomal subunit, blocking the approach to the elongating peptide's exit tunnel, which results in a premature release of peptidyl-tRNA intermediates. They compete with lincosamide antibiotics that are direct peptidyl transferase inhibitors.
- Julia Urban
Aug 11, 2020 · Inhibiting translation is one of the most common antibiotic modes of action, crucial for restraining pathogenic bacteria 1. Antibiotics targeting translation interfere with either the assembly...
- Bor Kavčič, Gašper Tkačik, Tobias Bollenbach
- 2020
Dec 16, 2013 · Most antibiotics that target the 50S subunit inhibit protein synthesis by either perturbing the binding of aminoacylated-tRNAs at the A- or P-sites or preventing the channelling of the...
- Daniel N. Wilson
- Wilson@genzentrum.lmu.de
- 2014
Jul 10, 2019 · When a bacterial pathogen is treated with a translation inhibitor, protein synthesis rapidly halts, leading to death or severe growth limitation. Current treatments inhibit translation through a variety of different strategies, ranging from directly targeting the ribosome to targeting aminoacyl tRNA (aa-tRNA) synthetases [ 1 – 5 ].
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Aug 11, 2020 · Antibiotics that interfere with translation, when combined, interact in diverse and difficult-to-predict ways. Here, we explain these interactions by "translation bottlenecks": points in the translation cycle where antibiotics block ribosomal progression.
