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Jul 22, 2021 · Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit protein synthesis by binding within the exit tunnel of the bacterial ribosome.
- Mechanisms of drug interactions between translation ... - Nature
Inhibiting translation is one of the most common antibiotic...
- Inhibition of translation termination by small molecules ...
The bacterial ribosome is an important drug target for...
- Mechanisms of drug interactions between translation ... - Nature
Dec 24, 2022 · Protein synthesis inhibitors work at different stages of prokaryotic mRNA translation into proteins like initiation, elongation (including aminoacyl tRNA entry, proofreading, peptidyl transfer, and ribosomal translocation), and termination.
Aug 11, 2020 · Inhibiting translation is one of the most common antibiotic modes of action, crucial for restraining pathogenic bacteria 1. Antibiotics targeting translation interfere with either the...
- Bor Kavčič, Gašper Tkačik, Tobias Bollenbach
- 2020
Oct 28, 2019 · The bacterial ribosome is an important drug target for antibiotics that can inhibit different stages of protein synthesis. Among the various classes of compounds that impair translation there...
- Xueliang Ge, Ana Oliveira, Karin Hjort, Terese Bergfors, Hugo Gutiérrez-de-Terán, Dan I Andersson, S...
- 2019
Because antibiotics inhibit protein synthesis by targeting specific functional centers of the ribosome, we discuss inhibitors based on their binding sites in the ribosome. We describe their modes of action, as well as prominent examples of the resistance mechanisms that have developed among pathogens.
Jan 1, 2024 · Antibiotics inhibit bacterial growth by affecting fundamental processes in cells, such as cell membrane biogenesis, DNA replication, RNA transcription and protein synthesis [111]. Importantly, protein biosynthesis is a major target and a majority of translation inhibitors directly target the ribosome [112].
Nov 11, 2014 · Macrolide antibiotics inhibit translation by binding in the ribosomal nascent peptide exit tunnel. It was believed that macrolides interfere with protein synthesis by obstructing the egress of nascent proteins.
