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1. www.ncbi.nlm.nih.gov › pmc › articlesSynovial sarcoma: characteristics, challenges, and evolving ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Aug 23, 2023 · Synovial sarcoma (SS) is a rare and malignant tumor of the connective tissues that presents challenges in diagnosis and treatment. 1,2 This article describes the epidemiology, clinical and genomic characteristics of SS, and the patient pathway from diagnosis to treatment.

   • Synovial Sarcoma: A Clinical Review - PMC

     Synovial sarcomas (SS) represent a unique subset of STS and...

   • Systemic Treatment for Adults with Synovial Sarcoma

     Synovial sarcoma (SS) is a rare, yet highly malignant, type...

2. www.ncbi.nlm.nih.gov › pmc › articlesSynovial Sarcoma: A Clinical Review - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   May 19, 2021 · Synovial sarcomas (SS) represent a unique subset of STS and account for 5–10% of all STS. Synovial sarcoma differs from other STS by the relatively young age at diagnosis, anatomic location (peri-articular) and clinical presentation (slow-growing, painful lesions).

   • Author: Aaron M. Gazendam, Snezana Popovic, Sohaib Munir, Naveen Parasu, David Wilson, Michelle Ghert
   • DOI: 10.3390/curroncol28030177

   • Publish Year: 2021
   • Publication: Curr Oncol. 2021 Jun; 28(3): 1909-1920.

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4. www.ncbi.nlm.nih.gov › pmc › articlesSystemic Treatment for Adults with Synovial Sarcoma

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 7, 2018 · Synovial sarcoma (SS) is a rare, yet highly malignant, type of soft tissue sarcoma (STS), for which survival has not improved significantly during the past years. In this review, we focus on systemic treatment in adults.

   • Author: Ingrid M. E. Desar, Emmy D. G. Fleuren, Winette T. A. van der Graaf

   • Publish Year: 2018

5. www.mdpi.com › 1718/7729/28-3 › 177Synovial Sarcoma: A Clinical Review - MDPI

   www.mdpi.com › 1718/7729/28-3 › 177

   • Cached

   May 19, 2021 · Synovial sarcomas (SS) represent a unique subset of STS and account for 5–10% of all STS. Synovial sarcoma differs from other STS by the relatively young age at diagnosis, anatomic location (peri-articular) and clinical presentation (slow-growing, painful lesions).

   • Author: Aaron M. Gazendam, Snezana Popovic, Sohaib Munir, Naveen Parasu, David Wilson, Michelle Ghert

   • Publish Year: 2021

6. ascopubs.org › doi › 10Synovial Sarcoma in Children, Adolescents, and Young Adults ...

   ascopubs.org › doi › 10

   Oct 8, 2021 · PDF. Abstract. Purpose. Synovial sarcoma (SS) is the second most common malignant soft tissue tumor in children. ARST0332 evaluated a risk-based treatment strategy for young patients with soft tissue sarcoma designed to limit therapy for low-risk (LR) disease and to test neoadjuvant chemoradiotherapy for unresected higher-risk disease. Methods.

   • Author: Rajkumar Venkatramani, Wei Xue, R Lor Randall, Suzanne Wolden, James Anderson, Dolores Lopez-Terrada...

   • Publish Year: 2021

7. ascopubs.org › doi › 10Synovial Sarcoma: Current Concepts and Future Perspectives

   ascopubs.org › doi › 10

   Dec 8, 2017 · Synovial sarcoma (SS) is a rare sarcoma driven by a translocation between SS18 and SSX 1, 2, or 4. With approximately 800 to 1,000 cases a year in the United States, it most commonly affects young adults between the ages of 15 and 30 years.

8. People also ask

   Is synovial sarcoma a subset of Sts?

   • Conclusions Synovial sarcomas (SS) represent a unique subset of STS and account for 5–10% of all STS. Synovial sarcoma differs from other STS by the relatively young age at diagnosis, anatomic location (peri-articular) and clinical presentation (slow-growing, painful lesions).

   Synovial Sarcoma: A Clinical Review - PMC - National Center

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8161765/

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   How common is synovial sarcoma (SS)?

   • Synovial sarcoma (SS) accounts for 5–10% of all STS [1, 2]. SS is an intriguing disease as, unlike the majority of STS, it can occur at any age and everywhere in the body. The peak incidence is in the 30s and it often presents in the extremities [3 •].

   Systemic Treatment for Adults with Synovial Sarcoma

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5842271/

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   How is synovial sarcoma treated?

   • Synovial sarcomas present with translocations affecting SS18 and SSX1, SSX2, SSX4 genes, whose protein products affects the transcriptional program of the cancer cell. Treatment of synovial sarcoma in localized phase follows the usual rules of sarcoma treatment, with uncertainties on the value of systemic treatment.

   Synovial sarcoma: characteristics, challenges, and evolving therapeutic

   www.ncbi.nlm.nih.gov/pmc/articles/PMC10470271/

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   What is a risk-based clinical trial for synovial sarcoma (SS)?

   • This is the first risk-based prospective clinical trial in children and young adults with synovial sarcoma (SS) in North America. The risk stratification was based on metastasis, tumor grade, tumor size, and extent of surgical resection.

   Synovial Sarcoma in Children, Adolescents, and Young Adults: A Report

   ascopubs.org/doi/10.1200/JCO.21.01628

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   Can pediatric adolescent patients with synovial sarcoma be treated without systemic therapy?

   • Recent data has demonstrated that pediatric or adolescent patients with low risk tumors (Grade 2 or Grade 3 < 5 cm) can be successfully treated with surgical intervention without systemic therapy [ 39 ]. The role of chemotherapy in adult patients with synovial sarcoma is less clear.

   Synovial Sarcoma: A Clinical Review - PMC - National Center

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8161765/

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   What is the prognosis of synovial sarcoma?

   • Synovial sarcomas with >20% poorly differentiated areas show more aggressive behaviour. The best outcomes are seen with tumors with histologic features <6 mitoses/mm 2 and no necrosis [ 3, 74 ]. Similar to other STS, tumor size and grade has repeatedly been shown to have prognostic value in patients with synovial sarcoma [ 48, 54, 67 ].

   Free Full-Text | Synovial Sarcoma: A Clinical Review - MDPI

   www.mdpi.com/1718-7729/28/3/177

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9. pubmed.ncbi.nlm.nih.gov › 30841761Standard treatment and emerging drugs for managing synovial ...

   pubmed.ncbi.nlm.nih.gov › 30841761

   in this review we discuss the standard of care for both pediatric and adult synovial sarcoma (SS), the prognostic differences between them, and the treatments available for localized and advanced diseases.